Results 91 to 100 of about 92,725 (287)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Cause and effect analysis for yield and grain quality traits in rice (Oryza sativa L.)
Electronic Journal of Plant Breeding, 2018 Character association studies with six field biometrics and nine grain quality traits recorded from 60 rice genotypes revealed that single plant yield was significantly correlated with number of filled grains per panicle (r = 0.516), and positively ...
M. Hemalatha +3 more
doaj +1 more source
Acceptability of UC781 Gel as a Rectal Microbicide Among HIV-Uninfected Women and Men [PDF]
, 2009 We studied the overall acceptability of UC781 gel formulation when applied rectally. Ten women and twenty-six men, all HIV-uninfected, were enrolled in a Phase 1, randomized, blinded, placebo-controlled safety and acceptability study of the vaginal ...
Elena Khanukhova +19 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Comparative Study on Amylose Content, Alkali Spreading and Gel Consistency of Rice.
Journal of the Japanese Society of Starch Science, 1991 The rice grain quality characteristics of 86 varieties from China, Japan, Korea and the Philippines were tested and found to be country- or region-specific to some extent. Analysis indicated that low amylose content, low gelatinization temperature and soft gel consistency were characteristics of Japanese varieties.
ZHANG, Xian-guang, SUZUKI, Hiroshi
openaire +2 more sources
KOBUNSHI RONBUNSHU, 2005 物理ゲルでも化学ゲルでもない第3のゲル, トポロジカルゲルは8の字架橋点で空間的 (位相幾何学的) な拘束により架橋する新しい高分子ゲルである. 大分子量のポリエチレングリコールに環状オリゴ糖であるシクロデキストリンが疎に充填されたポリロタキサンにおいて, シクロデキストリンどうしを8の字型に化学架橋して得られる. 環状分子が線状高分子に貫かれた状態で動くため環動ゲルとも呼ぶ. 8の字架橋点は高分子を自由に通して張力を均等に分配する, すなわち線状高分子に対して滑車のように振る舞う機能「滑車効果」をもつと考えられる. 実際のトポロジカルゲルは初期弾性率が特に小さく, また大変形に耐えて良く伸びる.
openaire +1 more source
To address the technical challenge of high polymer gel viscosity reducers losing viscosity at elevated temperatures and difficulty in controlling fluid loss, a polymer-based nano calcium carbonate composite high-temperature tackifier named GW-VIS was ...
Weijun Yan +3 more
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source