Results 71 to 80 of about 1,106,513 (284)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Plant, Soil and EnvironmentNitrogen fertiliser is a key determinant of rice yield and grain quality; however, the synergistic mechanisms through which nitrogen regulates root anatomical structure, physiological traits, and cooking quality in rice varieties with different eating ...
Li Wang +5 more
doaj +1 more source
Comparative Study on Amylose Content, Alkali Spreading and Gel Consistency of Rice.
Journal of the Japanese Society of Starch Science, 1991 The rice grain quality characteristics of 86 varieties from China, Japan, Korea and the Philippines were tested and found to be country- or region-specific to some extent. Analysis indicated that low amylose content, low gelatinization temperature and soft gel consistency were characteristics of Japanese varieties.
ZHANG, Xian-guang, SUZUKI, Hiroshi
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
BMC GenomicsRice eating and cooking quality (ECQ) is a key determinant of consumer preference and market value, governed by complex genetic and biochemical mechanisms.
Fatemeh Farzad Amirebrahimi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Cause and effect analysis for yield and grain quality traits in rice (Oryza sativa L.)
Electronic Journal of Plant Breeding, 2018 Character association studies with six field biometrics and nine grain quality traits recorded from 60 rice genotypes revealed that single plant yield was significantly correlated with number of filled grains per panicle (r = 0.516), and positively ...
M. Hemalatha +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
GelsThis study aimed to develop and evaluate hydrogels containing a cyclodextrin complex with clove essential oil and other free volatile oils with antimicrobial properties (tea tree and rosemary essential oils), focusing on their pharmaco-technical and ...
Alina Ionela Stancu +11 more
doaj +1 more source