Results 191 to 200 of about 160,832 (337)

Advances in the Diagnosis, Treatment, and Management of Liver Nodules: A Comprehensive Review

Portal Hypertension &Cirrhosis, EarlyView.
Liver nodules commonly occur due to various causes, some of which are malignant or may undergo malignant transformation, leading to disease progression or delayed detection in clinical practice. The widespread use of imaging methods has increased the detection rate of liver nodules. Furthermore, precision medicine techniques and artificial intelligence
Chang Gao, Dongyang Chen, Youpeng Chen
wiley   +1 more source

INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism. [PDF]

Cancer Cell Int
Sun X, Wei Z, Liao X, Zheng D, Li F, Chen L, Gong Y, Ran S, Han X, He Z, Yu C.   +10 more
europepmc   +1 more source

A Step‐by‐Step Workflow for Performing In Silico Clinical Trials With Nonlinear Mixed Effects Models

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT In silico clinical trials (ISCT) are computational frameworks that employ mathematical models to generate virtual patients and simulate their responses to new treatments, treatment regimens, or medical devices via simulations mirroring real‐world clinical trials.
Javiera Cortés‐Ríos, Mindy Magee, Anna Sher, William J. Jusko, Rajat Desikan   +4 more
wiley   +1 more source

Reappraising intravesical gemcitabine in BCG-unresponsive nonmuscle-invasive bladder cancer: lessons from contemporary re-analysis. [PDF]

Ann Med Surg (Lond)
Taj J, Ikkurthy N, Ekouo J.
europepmc   +1 more source

Toward Precision Chemotherapy for Pancreatic Cancer Guided by Transcriptomic Signatures

United European Gastroenterology Journal, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, with chemotherapy as the mainstay but highly variable efficacy and toxicity. Current regimens, such as FOLFIRINOX and gemcitabine‐based combinations, are selected empirically without validated biomarkers to guide choice.
Brice Chanez, Matthieu Delaye, Nicolas Fraunhoffer, Juan Iovanna, Cindy Neuzillet, Nelson Dusetti   +5 more
wiley   +1 more source

Real-world treatment outcomes in South Korean patients with epidermal growth factor receptor-mutant non-small cell lung cancer. [PDF]

Korean J Intern Med
Kim YS, Lee EY, Lee HW, Choi JH, Kim TH, Choi YW, Ahn MS.   +6 more
europepmc   +1 more source

Does Adjuvant Therapy in Invasive Intraductal Papillary Mucinous Neoplasm of the Pancreas Improve Survival? A Systematic Review and Meta‐Analysis Using Trial Sequential Analysis

World Journal of Surgery, EarlyView.
Question: What is the efficacy of adjuvant therapy in resected invasive IPMN? Findings: This meta‐analysis showed that patients with invasive IPMN do not benefit from adjuvant therapy (HR 1.21, 95% IC: 0.81−1.79). A subgroup analysis showed that node‐positive patients have an improved OS (HR 1.86; 95% CI 1.39; 2.47, p < 0.001).
Carlo Ingaldi, Vincenzo D'Ambra, Claudio Ricci, Laura Alberici, Marina Migliori, Mariacristina Di Marco, Andrea Palloni, Cristina Mosconi, Carla Serra, Riccardo Casadei   +9 more
wiley   +1 more source

The Effects of PAK-Regulated Tumour Vasculature on Gemcitabine Response of Pancreatic Cancer. [PDF]

Cancers (Basel)
Ansardamavandi A, Dumesny C, Ma Y, Dong L, Ellis S, Ang CS, Nikfarjam M, He H.   +7 more
europepmc   +1 more source

Phase 2 study of combination SPI-1620 with docetaxel as second-line advanced biliary tract cancer treatment [PDF]

, 2017
A Rai, AG Tolcher, AX Zhu, Caio Max S Rocha-Lima, David Portnoy, DP Brooks, E Gabriela Chiorean, E Suzuki, J Albores-Saavedra, J Nelson, J Valle, JE Rogers, JF Guion-Dussere, Jitendra Gandhi, L Goyal, M Yanagisawa, Manik Amin, NV Rajeshkumar, NV Rajeshkumar, P Papakostas, R Pazdur, Richard Kim, RK Jain, RL Siegel, S He, SC Lee, SY Oh, T Sasaki, T Walter, Tao Song, William P Harris   +30 more
core   +3 more sources

Efficacy of Capecitabine Plus Oxaliplatin Combination Chemotherapy for Advanced Pancreatic Cancer after Failure of First-Line Gemcitabine-Based Therapy

, 2016
Kwang Hyun Chung, Ji Kon Ryu, Jun Hyuk Son, Jae W. Lee, Dong Kee Jang, Sang Hyub Lee, Yong‐Tae Kim   +6 more
openalex   +2 more sources