Results 61 to 70 of about 1,076,570 (292)

Sex and Genotype Modulate the Dendritic Effects of Developmental Exposure to a Human-Relevant Polychlorinated Biphenyls Mixture in the Juvenile Mouse

Frontiers in Neuroscience, 2021
While many neurodevelopmental disorders (NDDs) are thought to result from interactions between environmental and genetic risk factors, the identification of specific gene-environment interactions that influence NDD risk remains a critical data gap.
Kimberly P. Keil Stietz, Sunjay Sethi, Carolyn R. Klocke, Tryssa E. de Ruyter, Machelle D. Wilson, Isaac N. Pessah, Pamela J. Lein   +6 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors. [PDF]

, 2016
The role of the cerebellum in motivation and addictive behaviors is less understood than that in control and coordination of movements. High running can be a self-rewarding behavior exhibiting addictive properties.
Caetano-Anollés, Kelsey, Garland, Theodore, Hernandez, Alvaro G, Perez, Sam D, Rhodes, Justin S, Rodriguez-Zas, Sandra L, Southey, Bruce R   +6 more
core   +2 more sources

Genotype by environment interaction for gene expression in Drosophila melanogaster

Nature Communications, 2020
Huang et al. show that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co-expression network remains robust.
Wen Huang, Mary Anna Carbone, Richard F. Lyman, Robert R. H. Anholt, Trudy F. C. Mackay   +4 more
doaj   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

The cultural epigenetics of psychopathology: The missing heritability of complex diseases found? [PDF]

, 2009
We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders.
Wallace, Rodrick
core   +1 more source

Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes. [PDF]

, 2020
Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language.
1000 Genomes Project C., A Adato, A Boyd, A Gialluisi, A Rimmer, A Van Aarem, A Vouloumanos, AA Benasich, AL Barabasi, BJ Keats, BR Shrestha, C Kilkenny, C Witton, CA Anderson, CC Brewer, CF Norbury, CF Reisser, CS Lai, D Szklarczyk, DF Newbury, DF Newbury, DR Moore, DR Moore, DV Bishop, E Eising, E Lenassi, G Conti-Ramsden, G Dehaene-Lambertz, G Lunter, GR Abecasis, J Golding, J Heckman, J Hornickel, JA Boughman, JC Barrett, JC Taylor, JM Ellingford, K Walter, K Wang, K Watanabe, L Huang, M Kircher, M Lek, M Luciano, M Van Segbroeck, MC Liberman, MEK Niemi, MG Filipe, MJ Henry, MR Bowl, N Pearsall, P Cingolani, P Danecek, P Le Quesne Stabej, R Mora, R Nudel, RH Fitch, RH Fitch, RM Rosenfeld, S Colella, S Lee, S Purcell, S Richards, S Shultz, SW Threlkeld, WJ Kent, WJ Kimberling, X Liu, X Zhan, XS Chen, Y Zhou, Y-M Tien   +71 more
core   +4 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

GEIRA: gene-environment and gene–gene interaction research application [PDF]

, 2011
The GEIRA (Gene-Environment and Gene–Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene–gene interaction analysis.
AJ MacGregor, B Ding, Bo Ding, CF Sing, CR Weinberg, DW Hosmer, F Cornelis, H Mahdi, Henrik Källberg, J Hallqvist, JH Moore, KJ Rothman, KJ Rothman, KJ Rothman, KJ Rothman, KJ Rothman, L Klareskog, L Klareskog, Lars Alfredsson, Lars Klareskog, Leonid Padyukov, LR Cardon, P Gorwood, P Stolt, RM Plenge, S Purcell, SF Assmann, T Andersson, TA Thornton-Wells, TJ VanderWeele   +29 more
core   +2 more sources