Results 21 to 30 of about 1,127,640 (282)

A flexible Bayesian model for studying gene-environment interaction. [PDF]

PLoS Genetics, 2012
An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence ...
Kai Yu, Sholom Wacholder, William Wheeler, Zhaoming Wang, Neil Caporaso, Maria Teresa Landi, Faming Liang   +6 more
doaj   +1 more source

The impact of imprecisely measured covariates on estimating gene-environment interactions [PDF]

, 2006
BACKGROUND The effects of measurement error in epidemiological exposures and confounders on estimated effects of exposure are well described, but the effects on estimates for gene-environment interactions has received rather less attention.
Cade, J.E., Gilthorpe, M.S., Greenwood, D.C.   +2 more
core   +2 more sources

Hawaiian Picture‐Winged Drosophila Exhibit Adaptive Population Divergence along a Narrow Climatic Gradient on Hawaii Island [PDF]

, 2019
1. Anthropogenic influences on global processes and climatic conditions are increasingly affecting ecosystems throughout the world. 2. Hawaii Island’s native ecosystems are well studied and local long‐term climatic trends well documented, making these ...
Bellinger, M. Renee, Eldon, Jon, Price, Donald K.   +2 more
core   +2 more sources

Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges

Sociological Science, 2020
Interest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies.
Benjamin W. Domingue, Sam Trejo, Emma Armstrong-Carter, Elliot M. Tucker-Drob   +3 more
doaj   +1 more source

Alcohol consumption and lifetime change in cognitive ability:a gene × environment interaction study [PDF]

, 2014
Studies of the effect of alcohol consumption on cognitive ability are often confounded. One approach to avoid confounding is the Mendelian randomization design.
AJ Birley, David C. Liewald, EJ Neafsey, F Panza, F Zanjani, G Davey Smith, Gail Davies, Geraldine McNeill, HK Seitz, Ian J. Deary, IHM Friesema, IJ Deary, IJ Deary, IJ Deary, J Corley, Janie Corley, John M. Starr, JW Kim, KJ Anstey, LF Masson, LM Hines, LM Houlihan, M Grønbæk, M Richards, M Zgombic-Knight, MA Collins, MF Folstein, Office of Population Censuses and Surveys, Office of Population Censuses and Surveys, P Brennan, PA Dickson, PL Brennan, S Ebrahim, S Sabia, Scottish Council for Research in Education, SJ Lewis, SL Au Yeung, Stuart J. Ritchie, Timothy C. Bates, Y Li   +39 more
core   +2 more sources

Candidate gene-environment interactions in substance abuse: A systematic review.

PLoS ONE, 2023
BackgroundThe abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders.
Zheng Jiang, Zidong Chen, Xi Chen
doaj   +1 more source

Metabolic syndrome, diabetes and atherosclerosis: Influence of gene-environment interaction [PDF]

, 2009
Despite remarkable progress in diagnosis and understanding of risk factors, cardiovascular disease (CVD) remains still the leading cause of morbidity and mortality in the world\u27s developed countries.
Andreassi, Maria Grazia
core   +1 more source

Artificial neural networks modeling gene-environment interaction

BMC Genetics, 2012
Background Gene-environment interactions play an important role in the etiological pathway of complex diseases. An appropriate statistical method for handling a wide variety of complex situations involving interactions between variables is still lacking,
Günther Frauke, Pigeot Iris, Bammann Karin   +2 more
doaj   +1 more source

Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium

Breast Cancer Research, 2023
Background Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among ...
Kristin L. Young, Andrew F. Olshan, Kathryn Lunetta, Mariaelisa Graff, Lindsay A. Williams, Song Yao, Gary R. Zirpoli, Melissa Troester, Julie R. Palmer   +8 more
doaj   +1 more source

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source