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BMC Bioinformatics, 2012 Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele +4 more
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American Journal of Epidemiology, 2017 Recently, many new approaches, study designs, and statistical and analytical methods have emerged for studying gene-environment interactions (G×Es) in large-scale studies of human populations.
K. McAllister +23 more
semanticscholar +1 more source
Gene-Environment Dependence Creates Spurious Gene-Environment Interaction [PDF]
The American Journal of Human Genetics, 2014 Gene-environment interactions have the potential to shed light on biological processes leading to disease and to improve the accuracy of epidemiological risk models. However, relatively few such interactions have yet been confirmed. In part this is because genetic markers such as tag SNPs are usually studied, rather than the causal variants themselves.
F. Dudbridge, O. Fletcher
semanticscholar +5 more sources
Gene–environment interactions in asthma [PDF]
Occupational and Environmental Medicine, 2006 Asthma is a complex disease with a diverse genetic and environmental component.1 Asthma shows a high level of phenotypic heterogeneity characterised by obstruction of the airways of the lung and is related with atopy, bronchial hyperresponsiveness (BHR), and increased IgE levels.
Manolis Kogevinas +3 more
openaire +3 more sources
A flexible Bayesian model for studying gene-environment interaction. [PDF]
PLoS Genetics, 2012 An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence ...
Kai Yu +6 more
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Scientific Reports, 2019 The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated gene-environment interaction between multiple genetic variants including HLA genes and smoking in sarcoidosis defined by two clinical phenotypes, Löfgren’s ...
Natalia V. Rivera +10 more
semanticscholar +1 more source
Gene‐environment interactions in childhood asthma revisited; expanding the interaction concept
Pediatric Allergy and Immunology, 2022 Investigation of gene‐environment interactions (GxE) may provide important insights into the gene regulatory framework in response to environmental factors of relevance for childhood asthma.
N. Hernandez-Pacheco +2 more
semanticscholar +1 more source
Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges
Sociological Science, 2020 Interest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies.
Benjamin W. Domingue +3 more
doaj +1 more source
Candidate gene-environment interactions in substance abuse: A systematic review.
PLoS ONE, 2023 BackgroundThe abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders.
Zheng Jiang, Zidong Chen, Xi Chen
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PLoS Genetics, 2017 Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci to be associated with body mass index (BMI) and risk of obesity.
M. Rask-Andersen +3 more
semanticscholar +1 more source