Results 121 to 130 of about 2,560,285 (288)

Nature, Nurture and Egalitarian Policy: What Can We Learn from Molecular Genetics? [PDF]

This brief paper draws attention to molecular genetic research which may provide a new dimension to our understanding of how socioeconomic outcomes are generated. In particular, we provide an overview of the recently emerging evidence of gene-environment
Lundborg, Petter, Stenberg, Anders
core  

Growth Hormone Gene Polymorphism and Its Association with Partial Cumulative Milk Yields of Holstein Friesian Dairy Cattle [PDF]

, 2012
Growth hormone gene (GH gene) plays an important role in regulating body growth and in developing mammary gland, similar with its interaction to specific receptors.
Andreas, E. (E), Anggraeni, A. (A), Misrianti, R. (R), Sumantri, C. (C)   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Characteristics of the phenotypes in prevalent and incident cases of heart failure in primary care: IBERICAN study

BMC Primary Care
Background The management in primary care (PC) of the patients with Heart Failure (HF) is different from the management hospital, in a special way compared to cardiology departments.
Sergio Cinza-Sanjurjo, Miguel Ángel Prieto-Díaz, Vicente Pallarés-Carratalá, Rafael M. Micó-Pérez, Sonsoles Velilla-Zancada, Alfonso Barquilla-García, Leovigildo Ginel-Mendoza, Antonio Segura-Fragoso, Vicente Martín-Sánchez, José Polo-García   +9 more
doaj   +1 more source

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Journal of Inflammation Research, 2022
Ruo-Xi Chen,1,* Meng-Di Dai,1,* Qing-Zhao Zhang,1 Mei-Ping Lu,1 Mei-Lin Wang,2,3 Min Yin,1,4 Xin-Jie Zhu,1 Zhong-Fei Wu,1 Zheng-Dong Zhang,2,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated ...
Chen RX, Dai MD, Zhang QZ, Lu MP, Wang ML, Yin M, Zhu XJ, Wu ZF, Zhang ZD, Cheng L   +9 more
doaj  

Mechanisms of resistance to viruses

Plant Protection Science, 2002
Resistance associated with a hypersensitive response (HR) and subsequent development of necrotic lesions (cell death) at the sites of virus infection can restrict virus movement in plants. Genes for HR are dominant and act on a gene-for-gene basis.
J.P.T. Valkonen
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study

Journal of Integrative Neuroscience
Background: Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date ...
Ksenia A. Kobzeva, Denis E. Gurtovoy, Alexey V. Polonikov, Vladimir M. Pokrovsky, Evgeny A. Patrakhanov, Olga Y. Bushueva   +5 more
doaj   +1 more source

Structural, Functional, and Evolutionary Characterization of Major Drought Transcription Factors Families in Maize

Frontiers in Chemistry, 2018
Drought is one of the major threats to the maize yield especially in subtropical production systems. Understanding the genes and regulatory mechanisms of drought tolerance is important to sustain the yield.
Shikha Mittal, Pooja Banduni, Mallana G. Mallikarjuna, Atmakuri R. Rao, Prashant A. Jain, Prasanta K. Dash, Nepolean Thirunavukkarasu   +6 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source