Results 21 to 30 of about 2,560,285 (288)
BMC Medical Genomics, 2021 Background Gamma-aminobutyric acid type A (GABAA) receptors mainly mediate the effects of gamma-aminobutyric acid, which is the primary inhibitory neurotransmitter in the central nervous system.
Sheue-Jane Hou +7 more
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Random matrix analysis for gene interaction networks in cancer cells [PDF]
, 2018 Investigations of topological uniqueness of gene interaction networks in cancer cells are essential for understanding this disease. Based on the random matrix theory, we study the distribution of the nearest neighbor level spacings $P(s)$ of interaction ...
Kikkawa, Ayumi
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Gene–gene interactions in APOL1-associated nephropathy [PDF]
Nephrology Dialysis Transplantation, 2013 Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non ...
Jasmin, Divers +9 more
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Statistical Indicators of Collective Behavior and Functional Clusters in Gene Networks of Yeast [PDF]
, 2005 We analyze gene expression time-series data of yeast S. cerevisiae measured along two full cell-cycles. We quantify these data by using q-exponentials, gene expression ranking and a temporal mean-variance analysis.
Tadic, Bosiljka +3 more
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Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases
G3: Genes, Genomes, Genetics, 2016 The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets.
William Murk, Andrew T. DeWan
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Gene-Based Methods to Detect Gene-Gene Interaction in R: The GeneGeneInteR Package
Journal of Statistical Software, 2020 GeneGeneInteR is an R package dedicated to the detection of an association between a case-control phenotype and the interaction between two sets of biallelic markers (single nucleotide polymorphisms or SNPs) in case-control genome-wide associations ...
Mathieu Emily +3 more
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Variants within the MMP3 gene are associated with achilles tendinopathy: possible interaction with the COL5A1 gene [PDF]
, 2009 Objectives: Sequence variation within the COL5A1 and TNC genes are known to associate with Achilles tendinopathy. The primary aim of this case-control genetic association study was to investigate whether variants within the matrix metalloproteinase 3 ...
Collins, M +5 more
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Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. [PDF]
, 2010 Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency.
Bethi, SR +5 more
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A network view of human immune system and virus-human interaction
Frontiers in Immunology, 2022 The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and ...
Kang Tang +24 more
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Identifying gene‐gene interactions using penalized tensor regression [PDF]
Statistics in Medicine, 2017 Gene‐gene (G×G) interactions have been shown to be critical for the fundamental mechanisms and development of complex diseases beyond main genetic effects. The commonly adopted marginal analysis is limited by considering only a small number of G factors at a time. With the “main effects, interactions” hierarchical constraint, many of the existing joint
Mengyun Wu, Jian Huang, Shuangge Ma
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