Results 41 to 50 of about 2,560,285 (288)
A genetic ensemble approach for gene-gene interaction identification
BMC Bioinformatics, 2010 Background It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases.
Ho Joshua WK +3 more
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Gene-centric gene-gene interaction: A model-based kernel machine method
, 2012 Much of the natural variation for a complex trait can be explained by variation in DNA sequence levels. As part of sequence variation, gene-gene interaction has been ubiquitously observed in nature, where its role in shaping the development of an ...
Cui, Yuehua, Li, Shaoyu
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Identification of gene-gene interaction using principal components [PDF]
BMC Proceedings, 2009 Abstract After more than 200 genome-wide association studies, there have been some successful identifications of a single novel locus. Thus, the identification of single-nucleotide polymorphisms (SNP) with interaction effects is of interest.
Li, Jia +3 more
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Efficient regularized isotonic regression with application to gene--gene interaction search
, 2012 Isotonic regression is a nonparametric approach for fitting monotonic models to data that has been widely studied from both theoretical and practical perspectives.
Luss, Ronny +2 more
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Dual gene activation and knockout screen reveals directional dependencies in genetic networks. [PDF]
, 2018 Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins
Biton, Anne +12 more
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Machine Learning for Detecting Gene-Gene Interactions [PDF]
Applied Bioinformatics, 2006 Complex interactions among genes and environmental factors are known to play a role in common human disease aetiology. There is a growing body of evidence to suggest that complex interactions are 'the norm' and, rather than amounting to a small perturbation to classical Mendelian genetics, interactions may be the predominant effect.
Brett A, McKinney +3 more
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Gene-Gene Interaction Analysis In Alzheimer
International Journal of Computer Science and Information Technology, 2018 ABSTRACT Genome-wide transcription profiling is a powerful technique in studying disease susceptible footprints. Moreover, when applied to disease tissue it may reveal quantitative and qualitative alterations in gene expression that give information on the context or underlying basis for the disease and may provide a new diagnostic approach.
Rishi Yadav, Ravi Bhushan Mishra
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Modeling Gene-Gene Interactions Using Graphical Chain Models [PDF]
Human Heredity, 2007 <i>Objective:</i> To investigate whether graphical chain models are suitable to detect gene-gene interaction under different biological models. <i>Methods:</i> We conducted a simulation study comparing graphical chain models with logistic regression models regarding their ability to detect underlying biological interaction ...
Ronja, Foraita +2 more
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Taiwanese Journal of Psychiatry, 2019 Background: Vascular endothelial growth factor A (VEGFA) and brain-derived neurotrophic factor (BDNF), the most abundant and widely expressed neurotrophic factors in the brain, are believed to play an important rôle in depression and anxiety.
Eugene Lin +4 more
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Diverged and Active Partitiviruses in Lichen
Frontiers in Microbiology, 2020 The lichen is a microbial consortium that mainly consists of fungi and either algae (Viridiplantae) or cyanobacteria. This structure also contains other bacteria, fungi, and viruses.
Syun-ichi Urayama +11 more
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