Results 101 to 110 of about 5,291,226 (319)

Exploring the Potential Molecular Mechanism of Sijunzi Decoction in the Treatment of Non-Segmental Vitiligo Based on Network Pharmacology and Molecular Docking

Clinical, Cosmetic and Investigational Dermatology, 2023
Ziwei Du,1 Hepeng Wang,1 Yang Gao,1 Shumao Zheng,1 Xiaoli Kou,1 Guoqiang Sun,1 Jinxian Song,2 Jingfei Dong,3 Genhui Wang4 1Department of Dermatology, Hebei Academy of Traditional Chinese Medicine, Shijiazhuang, Hebei, 050031, People’s Republic of China ...
Du Z, Wang H, Gao Y, Zheng S, Kou X, Sun G, Song J, Dong J, Wang G   +8 more
doaj  

Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor κB [PDF]

, 2002
Zhiyuan Yu, Wenzheng Zhang, Bruce C. Kone   +2 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Papillon-Lefevre Syndrome

Česká Stomatologie a Praktické Zubní Lékařství, 2009
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by severe early-onset periodontal destruction involving both the deciduous and permanent dentition and skin lesions of palmoplantar hyperkeratosis. Recently it was found
L. Izakovičová Hollá, A. Fassmann, M. Kukletová, V. Sazmová   +3 more
doaj  

Angiogenic Gene Therapy for Experimental Critical Limb Ischemia [PDF]

, 2002
Ichiro Masaki, Yoshikazu Yonemitsu, Akihisa Yamashita, Shihoko Sata, Mitsugu Tanii, Kimihiro Komori, Kazunori Nakagawa, Xiaogang Hou, Yoshiyuki Nagai, Mamoru Hasegawa, Keizō Sugimachi, Katsuo Sueishi   +11 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression [PDF]

, 2022
Avital Sarusi-Portuguez, Ivana Grbeša, Moran Tal, Rachel Deitch, Dana Raz, Limor Kliker, Ran Weismann, Michal Schwartz, Olga Loza, Leslie E. Cohen, Libi Marchenkov-Flam, Myong‐Hee Sung, Tommy Kaplan, Ofir Hakim   +13 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition [PDF]

, 2018
Jessica A. Deaver, Sung Yong Eum, Michał Toborek   +2 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source