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Gene Dosage and Gene Duplicability [PDF]
Genetics, 2008 Abstract The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more ...
Wenfeng, Qian, Jianzhi, Zhang
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Genotypic and clinical analysis of 49 Chinese children with hepatic glycogen storage diseases
Molecular Genetics & Genomic Medicine, 2020 Background Glycogen storage disease (GSD) is a relatively rare inborn metabolic disorder, our study aims to investigate the genotypic and clinical feature of hepatic GSDs in China.
Yan Liang +7 more
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The Epidermis: Genes On – Genes Off
Journal of Investigative Dermatology, 1997 The epidermal keratinocyte stem cell is distinguished by a relatively undifferentiated phenotype and an ability to proliferate. As part of a carefully orchestrated process, the offspring of these stem cells lose the ability to proliferate and begin a process of morphologic and biochemical transformation that results in their conversion into corneocytes.
Eckert, Richard L. +3 more
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miGAP: miRNA–Gene Association Prediction Method Based on Deep Learning Model
Applied Sciences, 2023 MicroRNAs (miRNAs) are small RNA molecules consisting of approximately 22 nucleotides; they regulate gene expression and are employed in the development of therapeutics for intractable diseases.
Seungwon Yoon +4 more
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Animals, 2023 As a common influencing factor in the environment, temperature greatly influences the fish that live in the water all their life. The essential economic fish Chinese tongue sole (Cynoglossus semilaevis), a benthic fish, will experience both physiological
Yue Wang +9 more
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BMJ, 2003 To the Medical Research Council, currently enjoying the warmth of celebrations marking the 50th anniversary of Crick and Watson's discovery of the double helix at an MRC laboratory, last week's report by the House of Commons science and technology committee must have felt like a bucket of ice cold water.
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Gene-Gene and Gene-Environment Interactions in Mild Hyperhomocysteinemia [PDF]
Pathophysiology of Haemostasis and Thrombosis, 2003 Mild/moderate hyperhomocysteinemia (HHcy), a highly prevalent condition, is independently associated with an increased risk of arterial and venous thromboembolic diseases. Early reports of the association of mild/moderate HHcy with juvenile venous thromboembolism have shown familiarity for HHcy in relatives of index cases with thrombosis.
D'Angelo, Armando +2 more
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Identifying molecular subgroups of patients with preeclampsia through bioinformatics
Frontiers in Cardiovascular MedicinePreeclampsia (PE) is a pregnancy-related disorder associated with serious complications. Its molecular mechanisms remain undefined; hence, we aimed to identify molecular subgroups of patients with PE using bioinformatics to aid treatment strategies.
Huijie Zhang, Jianglei Ma, Xueli Gao
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Omnibus testing approach for gene‐based gene‐gene interaction
Statistics in Medicine, 2022 AbstractGenetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the SNP level have been proposed.
Hébert, Florian +2 more
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Gene–gene and gene–environment interactions in ulcerative colitis [PDF]
Human Genetics, 2013 Genome-wide association studies (GWAS) have identified at least 133 ulcerative colitis (UC) associated loci. The role of genetic factors in clinical practice is not clearly defined. The relevance of genetic variants to disease pathogenesis is still uncertain because of not characterized gene-gene and gene-environment interactions.
Ming-Hsi, Wang +7 more
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