Results 41 to 50 of about 3,996,156 (269)

Marfan syndrome: insights from animal models

Frontiers in Genetics
Marfan syndrome (MFS) is an inherited disorder that affects the connective tissues and mainly presents in the bones, eyes, and cardiovascular system, etc. Aortic pathology is the leading cause of death in patients with Marfan syndrome.
Yuanyuan Jiang, Ping Jia, Xiaoying Feng, Dingding Zhang   +3 more
doaj   +1 more source

The comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on viability, apoptosis, and gene expression of human prostate cancer cells

Journal of Current Biomedical Reports, 2023
Globally, the most prevalent medical condition affecting males is identified as prostate cancer (PCa). The aim of the present study was the comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on several laboratory ...
Mohamadreza Savaee, Ali Bakhshi, Mehran Dehghanian, Ghafour Yarahmadi, Fatemeh Yaghoubi, Fatemeh Pourrajab   +5 more
doaj   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source

Reproductive ability of cows of domestic dairy breeds with different allelic variants of the leptin gene

Аграрная наука Евро-Северо-Востока, 2022
Conducting genetic studies of domestic local breeds of cattle is relevant due to the fact that they are carriers of valuable economic traits and have a high adaptive ability to local conditions.
A. D. Lemyakin, A. N. Tyazhchenko, K. D. Sabetova, A. A. Chaitsky, P. O. Shchegolev, A. A. Korolev   +5 more
doaj   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Leukemia and Exposure to Potential Benzene Sources in Children From the Mexico City Metropolitan Area, 2010–2021: A Geospatial Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Leukemia is the most common childhood cancer in Mexico, and acute lymphoblastic leukemia (ALL) is the most frequent subtype. Exposure to high concentrations of benzene has been associated with ALL incidence, particularly in urban areas. This study evaluated the relationship between distance to benzene emission sources and the number
Orlando Rivera Zurita, Norma Candelaria López Santiago, Claudia Maria García Cuellar, Karla Maldonado Silva, Nancy Reynoso Noverón, Leticia Hernández Cadena   +5 more
wiley   +1 more source

Effects of candidate genes on milk fat synthesis in ruminants: A meta-analysis

Journal of Dairy Science
: Milk fat content is a polygenic commercially important quantitative trait in ruminants. In recent decades, an increasing number of genes involved in milk fat synthesis have been identified through GWAS and validated using functional assays, such as ...
Lily Liu, Wenquan Yan, Min Yan, Songlin Liu, Qin Zhang, Emily Clark, Jinhai Wang   +6 more
doaj   +1 more source

GEIRA: gene-environment and gene–gene interaction research application [PDF]

European Journal of Epidemiology, 2011
The GEIRA (Gene-Environment and Gene-Gene Interaction Research Application) algorithm and subsequent program is dedicated to genome-wide gene-environment and gene-gene interaction analysis. It implements concepts of both additive and multiplicative interaction as well as calculations based on dominant, recessive and co-dominant genetic models ...
Ding, Bo, Källberg, Henrik, Klareskog, Lars, Padyukov, Leonid, Alfredsson, Lars   +4 more
openaire   +3 more sources

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis

Shanghai Jiaotong Daxue xuebao. Yixue ban
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes,
ZHANG Zongwen, FENG Li, FAN Zhisong
doaj   +1 more source