The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Association of single nucleotide variants of the SLCO1B1 gene with the Gilbert syndrome phenotype
Бюллетень сибирской медициныThe aim of the study is to investigate the association of rs2306283 and rs4149056 variants of the SLCO1B1 gene with benign unconjugated hyperbilirubinemia. Materials and methods. A case-control study design was employed.
A. A. Ivanova +7 more
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Trans Effects on Gene Expression Can Drive Omnigenic Inheritance [PDF]
, 2019 Xuanyao Liu +2 more
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The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma
Frontiers in Oncology, 2018 Malignant pleural mesothelioma (MPM) is a rare, but severe form of cancer, with an incidence that varies significantly within and among different countries around the world.
Marika Rossini +7 more
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Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study [PDF]
, 2013 Philippa J. Talmud +18 more
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Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Iraqi Journal of HematologyBACKGROUND: Chronic myeloid leukemia (CML) is a type of cancer that originates in hematopoietic stem cells, particularly those that develop into myeloid cells.
Yusur Falah Faraj
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Brain Cell Type Specific Gene Expression and Co-expression Network Architectures [PDF]
, 2018 Andrew McKenzie +10 more
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source