Mutualism Breakdown by Amplification of Wolbachia Genes
PLOS Biology, 2015 Most insect species are associated with vertically transmitted endosymbionts. Because of the mode of transmission, the fitness of these symbionts is dependent on the fitness of the hosts. Therefore, these endosymbionts need to control their proliferation in order to minimize their cost for the host.
Chrostek, Ewa, Teixeira, Luis
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Analysis of DNA Polymerases Reveals Specific Genes Expansion in Leishmania and Trypanosoma spp.
Frontiers in Cellular and Infection Microbiology, 2020 Leishmaniasis and trypanosomiasis are largely neglected diseases prevailing in tropical and subtropical conditions. These are an arthropod-borne zoonosis that affects humans and some animals and is caused by infection with protozoan of the genera ...
Ana Poveda +3 more
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Gene-amplification model of carcinogenesis. [PDF]
Proceedings of the National Academy of Sciences, 1981 A two-stage model of carcinogenesis is proposed based on recent evidence for the occurrence of proto-oncogenes in the vertebrate genome, evidence for gene amplification during carcinogenesis, and studies of the action of tumor promoters. The model is baed on the view that an increase in the level of gene product from such proto-oncogenes is sufficient ...
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Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S. +3 more
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Amplification efficiency and thermal stability of qPCR instrumentation: Current landscape and future perspectives [PDF]
, 2015 This is a final draft version of the publication following acceptance by the journal.Quantitative polymerase chain reaction (qPCR) is a method of amplifying and detecting small samples of genetic material in real time and is in routine use across many ...
Karteris, E, Rogers-Broadway, KR
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Mechanism of Gene Amplification via Yeast Autonomously Replicating Sequences
The Scientific World Journal, 2015 The present investigation was aimed at understanding the molecular mechanism of gene amplification. Interplay of fragile sites in promoting gene amplification was also elucidated.
Shelly Sehgal, Sanjana Kaul, M. K. Dhar
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A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. [PDF]
, 2019 Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage.
Bier, Ethan +3 more
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An efficient protocol to perform genetic traceability of tissue and foods from Geoffroea decorticans
, 2019 The quality of a DNA isolation method depends, among others, on the target tissue and the metabolites therein. Geoffroea decorticans Burkart (chanar) is a species that has nutritional and pharmacological potential.
Aguayo, F. +3 more
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Human Cytomegalovirus: detection of congenital and perinatal infection in Argentina [PDF]
, 2004 BACKGROUND: Human cytomegalovirus (CMV) is one of the most commonly found agents of congenital infections. Primary maternal infection is associated with risk of symptomatic congenital diseases, and high morbidity is frequently associated with very low ...
Alicia Alonso +25 more
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mBio, 2018 Although the TEM-1 β-lactamase (BlaTEM-1) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However,
Lisa M. Schechter +11 more
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