Results 111 to 120 of about 8,013,600 (393)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Species Authentication of Dog, Cat, and Tiger Using Cytochrome Β Gene [PDF]

, 2013
Adulteration of animal food products for economic reason has happened during the last decades. Species identification method development was needed to prevent falsification information.
Irine, I. (Irine), Nuraini, H. (H), Sumantri, C. (C)   +2 more
core  

Real-time PCR based on SYBR-Green I fluorescence: An alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions [PDF]

, 2003
BACKGROUND: Real-time PCR is increasingly being adopted for RNA quantification and genetic analysis. At present the most popular real-time PCR assay is based on the hybridisation of a dual-labelled probe to the PCR product, and the development of a ...
Bell, S.M., Bransfield, K., Combaret, V., Douglas, S.H., Field, S.L., Inglehearn, C.F., Isaacs, J.D., Leong, F.T., Markham, A.F., Mighell, A.J., Ponchel, F., Puisieux, A., Robinson, P.A., Toomes, C.   +13 more
core   +3 more sources

HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy

Journal of Translational Medicine, 2012
Background HER2 and TOP2A parameters (gene status, mRNA and protein expression) have individually been associated with the outcome of patients treated with anthracyclines.
Fountzilas George, Valavanis Christos, Kotoula Vassiliki, Eleftheraki Anastasia G, Kalogeras Konstantine T, Tzaida Olympia, Batistatou Anna, Kronenwett Ralf, Wirtz Ralph M, Bobos Mattheos, Timotheadou Eleni, Soupos Nikolaos, Pentheroudakis George, Gogas Helen, Vlachodimitropoulos Dimitrios, Polychronidou Genovefa, Aravantinos Gerasimos, Koutras Angelos, Christodoulou Christos, Pectasides Dimitrios, Arapantoni Petroula   +20 more
doaj   +1 more source

Gene-amplification model of carcinogenesis. [PDF]

Proceedings of the National Academy of Sciences, 1981
A two-stage model of carcinogenesis is proposed based on recent evidence for the occurrence of proto-oncogenes in the vertebrate genome, evidence for gene amplification during carcinogenesis, and studies of the action of tumor promoters. The model is baed on the view that an increase in the level of gene product from such proto-oncogenes is sufficient ...
openaire   +3 more sources

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Mutations and amplification of oncogenes in endometrial cancer [PDF]

, 1999
Alterations in oncogenes are critical steps in the development of endometrial cancer. To investigate the potential clinical relevance of the amplification of the oncogenes c-erbB2, c-myc, and int-2 and the mutation of K-ras in endometrial cancer, 112 ...
An, Han-Xiang, Beckmann, Matthias W., Bender, Hans G., Cho, Yong-Jig, Hantschmann, Peer, Niederacher, Dieter   +5 more
core   +1 more source

The prevalence of Fibroblast Growth Factor Receptor 1 Gene (FGFR1) amplification in Non-Small Cell Lung Cancer (NSCLC) by Real-time PCR [PDF]

Caspian Journal of Internal Medicine
Background: Comprehensive molecular assessment of cancers could open up new horizons for novel therapies. Fibroblast growth factor receptor 1 (FGFR1) gene amplification has been previously demonstrated in non-small cell lung cancer (NSCLC) patients.
Sanaz Homayounfar, Hossein Ayatollahi, Gordon Ferns, Reza Hemmatan Attarbashi, Masoumeh Gharib, Maryam Sheikhi, Zahra Khoshnegah, Payam Siyadat, Amirhossein Jafarian   +8 more
doaj  

Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli

mBio, 2018
Although the TEM-1 β-lactamase (BlaTEM-1) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However,
Lisa M. Schechter, David P. Creely, Cherilyn D. Garner, Dee Shortridge, Hoan Nguyen, Lei Chen, Blake M. Hanson, Erica Sodergren, George M. Weinstock, W. Michael Dunne, Alex van Belkum, Shana R. Leopold   +11 more
doaj   +1 more source

FGFR2 gene amplification and clinicopathological features in gastric cancer

British Journal of Cancer, 2012
Background:Frequency of FGFR2 amplification, its clinicopathological features, and the results of high-throughput screening assays in a large cohort of gastric clinical samples remain largely unclear.Methods:Drug sensitivity to a fibroblast growth factor
Kazuko Matsumoto, T. Arao, T. Hamaguchi, Y. Shimada, K. Kato, I. Oda, H. Taniguchi, F. Koizumi, K. Yanagihara, Hiroki Sasaki, K. Nishio, Y. Yamada   +11 more
semanticscholar   +1 more source