Results 71 to 80 of about 208,264 (275)

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

open access: yesFEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta   +3 more
wiley   +1 more source

GARNET – gene set analysis with exploration of annotation relations

open access: yesBMC Bioinformatics, 2011
Background Gene set analysis is a powerful method of deducing biological meaning for an a priori defined set of genes. Numerous tools have been developed to test statistical enrichment or depletion in specific pathways or gene ontology (GO) terms.
Seo Jihae   +12 more
doaj   +1 more source

DROPA: DRIP-seq optimized peak annotator

open access: yesBMC Bioinformatics, 2019
Background R-loops are three-stranded nucleic acid structures that usually form during transcription and that may lead to gene regulation or genome instability.
Marco Russo   +5 more
doaj   +1 more source

Multiple tests of association with biological annotation metadata

open access: yes, 2008
We propose a general and formal statistical framework for multiple tests of association between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest.
Mark J. Van Der Laan   +4 more
core   +2 more sources

The dual nature of TDC – bridging dendritic and T cells in immunity

open access: yesFEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Gene Annotation Easy Viewer (GAEV): Integrating KEGG’s Gene Function Annotations and Associated Molecular Pathways [version 3; peer review: 1 approved, 2 approved with reservations]

open access: yesF1000Research, 2019
We developed a Gene Annotation Easy Viewer (GAEV) that integrates the gene annotation data from the KEGG (Kyoto Encyclopedia of Genes and Genomes) Automatic Annotation Server.
Trung Huynh, Sen Xu
doaj   +1 more source

A biophysical approach to large-scale protein-DNA binding data [PDF]

open access: yes, 2008
About this book * Cutting-edge genome analysis methods from leading bioinformaticians An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens ...
Manke, T., Roider, H., Vingron, M.
core   +1 more source

Using the Gene Ontology to Annotate Key Players in Parkinson's Disease [PDF]

open access: yes, 2016
The Gene Ontology (GO) is widely recognised as the gold standard bioinformatics resource for summarizing functional knowledge of gene products in a consistent and computable, information-rich language.
Denny, P   +5 more
core   +2 more sources

Gene Characterization Index: Assessing the Depth of Gene Annotation

open access: yesPLoS ONE, 2008
We introduce the Gene Characterization Index, a bioinformatics method for scoring the extent to which a protein-encoding gene is functionally described. Inherently a reflection of human perception, the Gene Characterization Index is applied for assessing the characterization status of individual genes, thus serving the advancement of both genome ...
Wyeth W. Wasserman   +10 more
openaire   +4 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

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