Results 11 to 20 of about 838,531 (316)

Gene deletion by synthesis in yeast

, 2017
Targeted gene deletion is a useful tool for understanding the function of a gene and its protein product. We have developed an efficient and robust gene deletion approach in yeast that employs oligonucleotidebased gene synthesis. This approach requires a
K L Hoe, Jinsil Kim, Dong Uk Kim
core   +3 more sources

Interstitial Deletions Generating Fusion Genes [PDF]

Cancer Genomics - Proteomics, 2021
A fusion gene is the physical juxtaposition of two different genes resulting in a structure consisting of the head of one gene and the tail of the other. Gene fusion is often a primary neoplasia-inducing event in leukemias, lymphomas, solid malignancies as well as benign tumors.
Panagopoulos, Ioannis, Heim, Sverre
openaire   +3 more sources

Akt1 gene deletion and stroke [PDF]

Journal of the Neurological Sciences, 2008
Activation of Akt has been implicated as a major contributor to neuronal survival after an ischemic insult. Numerous neuroprotective agents have been shown to augment Akt activity, suggesting that this protein represents a major mechanism of cellular salvage after injury.
Jun, Li, Jesse, Lang, Zhiyuan, Zeng, Louise D, McCullough   +3 more
openaire   +2 more sources

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Construction and characterization of a glycoprotein E deletion mutant of bovine herpesvirus type 1.2 strain isolated in Brazil [PDF]

, 2002
This paper describes the construction and characterization of a Brazilian strain of bovine herpesvirus type 1.2a (BoHV-1.2a) with a deletion of the glycoprotein E (gE) gene. The deletion was introduced by co-transfection of a deletion fragment containing
Rijsewijk, F.A.M., Franco, A.C., Flores, E.F., Weiblen, R., Roehe, P.M.   +4 more
core   +1 more source

Rac1 Deletion Causes Thymic Atrophy [PDF]

, 2011
The thymic stroma supports T lymphocyte development and consists of an epithelium maintained by thymic epithelial progenitors. The molecular pathways that govern epithelial homeostasis are poorly understood.
Glogauer Michael, Wright, Nick A, Geoff Laurent, Watt, FM, Janes, Sam M., Kristin M Braun, Emma Nye, Potton, E, Braun, Kristin M., Fiona M. Watt, Janes, Sam M, Katrina McNulty, Butler, Colin, Potton Elspeth, Glogauer, Michael, Wright, NA, Colin Butler, Benitah, Salvador Aznar, Potton, Elspeth, Aznar Benitah Salvador, Boyd, Richard, Jensen, K, Richard Boyd, Braun, Kristin M, Salvador Aznar Benitah, Butler Colin, Sam M Janes, Hunziker, L, Laurent, G, McNulty, Katrina, Elspeth Potton, Janes Sam M., Watt, Fiona M; id_orcid, Boyd, R, Nick A Wright, Kristin M. Braun, Nye, Emma, Laurent Geoff, Michael Glogauer, Wright Nick A., Nye, E, Butler, C, Braun, Kristin, Jensen Kim, Nye Emma, Wright, Nick A., McNulty, Ksatrina, Lukas Hunziker, Glogauer, M, McNulty Katrina, Sam M. Janes, Braun, KM, Laurent, Geoff, Hunziker Lukas, Watt, Fiona, Kim Jensen, Benitah, SA, Nick A. Wright, Watt Fiona M., McNulty, K, Boyd Richard, Fiona M Watt, Wright, Nick, Braun Kristin M., Watt, Fiona M., Jensen, Kim, Janes, SM, Hunziker, Lukas, Aznar Benitah, Salvador, Benitah, Salvador, Janes, Sam   +70 more
core   +1 more source

Enhancement of Cellulase Production in Trichoderma reesei via Disruption of Multiple Protease Genes Identified by Comparative Secretomics

Frontiers in Microbiology, 2019
The filamentous fungus Trichoderma reesei is one of the most studied cellulolytic organisms and the major producer of cellulases for industrial applications.
Yuanchao Qian, Lixia Zhong, Yu Sun, Ningning Sun, Lei Zhang, Weifeng Liu, Yinbo Qu, Yaohua Zhong   +7 more
doaj   +1 more source

Effects of Four Critical Gene Deletions in Saccharomyces cerevisiae on Fusel Alcohols during Red Wine Fermentation

Fermentation, 2023
Excessive fusel alcohols in red wine will bring an uncomfortable bitterness and generate an intoxicating effect, which affects the quality and attractivity of the red wine. In order to achieve better regulation of fusel alcohols in red wine, strains with
Tongshuai Yan, Zexiang Wang, Haoyang Zhou, Jiaojiao He, Shishui Zhou   +4 more
doaj   +1 more source

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. [PDF]

, 2007
Sepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution
Kreth Simone, Sitkovsky Michail V., Sitkovsky, Michail V., Alex B Lentsch, Lukashev, Dmitry, Lentsch Alex B., Michail V Sitkovsky, Kreth, Simone, Smith Patrick, Smith, Patrick, Kuboki, Satoshi, P Chen, Caldwell Charles C., Lukashev Dmitry, Akio Ohta, Manfred Thiel, Chen P., Caldwell, Charles C., Lentsch, Alex B., Dmitry Lukashev, Chen, P., Patrick Smith, Kuboki Satoshi, Satoshi Kuboki, Thiel, Manfred, Ohta, Akio, Thiel Manfred, Ohta Akio, Charles C Caldwell, Simone Kreth   +29 more
core   +1 more source

Two novel Bartonella (sub)species isolated from edible dormice (Glis glis): hints of cultivation stress-induced genomic changes

Frontiers in Microbiology, 2023
Bartonelloses are neglected emerging infectious diseases caused by facultatively intracellular bacteria transmitted between vertebrate hosts by various arthropod vectors. The highest diversity of Bartonella species has been identified in rodents.
Oldřich Bartoš, Běla Klimešová, Karolina Volfová, Martin Chmel, Martin Chmel, Jiří Dresler, Petr Pajer, Hana Kabíčková, Peter Adamík, Peter Adamík, David Modrý, David Modrý, David Modrý, Alena Myslivcová Fučíková, Jan Votýpka, Jan Votýpka   +15 more
doaj   +1 more source