Gene Expression in
mBio, 2017 Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Stefano A. Iantorno +9 more
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Frontiers in Plant Science, 2016 Gene/genome dosage balance is an essential evolutionary mechanism for organisms to ensure a normal function, but the underlying causes of dosage-imbalance regulation remain poorly understood.
C David, T Ekelof
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Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution [PDF]
bioRxiv, 2017 Mammalian X and Y Chromosomes evolved from an ordinary autosomal pair. Genetic decay of the Y led to X Chromosome inactivation (XCI) in females, but some Y-linked genes were retained during the course of sex chromosome evolution, and many X-linked genes ...
Bellott, Daniel W. +3 more
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Brain region and gene dosage-differential transcriptomic changes in Shank2-mutant mice [PDF]
Frontiers in Molecular Neuroscience, 2022 Shank2 is an abundant excitatory postsynaptic scaffolding protein that has been implicated in various neurodevelopmental and psychiatric disorders, including autism spectrum disorder (ASD), intellectual disability, attention-deficit/hyperactivity ...
Ye-Eun Yoo +4 more
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Gene dosage compensation: Origins, criteria to identify compensated genes, and mechanisms including sensor loops as an emerging systems‐level property in cancer [PDF]
Cancer Medicine, 2023 The gene dosage compensation hypothesis presents a mechanism through which the expression of certain genes is modulated to compensate for differences in the dose of genes when additional chromosomes are present.
Diana M. Bravo‐Estupiñan +6 more
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Single cell transcriptome in aneuploidies reveals mechanisms of gene dosage imbalance
Nature Communications, 2019 Gene dosage anomalies such as those caused by aneuploidy underlie diseases including Down syndrome. Here, the authors perform allele-specific single cell transcriptome analysis to investigate the mechanisms of gene dosage imbalance in fibroblasts with ...
Georgios Stamoulis +11 more
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Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria [PDF]
eLifeEvolution of gene expression frequently drives antibiotic resistance in bacteria. We had previously (Patel and Matange, eLife, 2021) shown that, in Escherichia coli, mutations at the mgrB locus were beneficial under trimethoprim exposure and led to ...
Chinmaya Jena +3 more
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Balanced gene dosage control rather than parental origin underpins genomic imprinting [PDF]
Nature Communications, 2022 Here the authors investigate whether for imprinted genes the parent-of-origin of the expressed allele or rather appropriate gene dosage is more important for normal development.
Ariella Weinberg-Shukron +7 more
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Gene dosage effects of poly(A) track-engineered hypomorphs [PDF]
Molecular Therapy: Nucleic Acids, 2021 Manipulation of gene activity through creation of hypomorphic mutants has been a long-standing tool in examining gene function. Our previous studies have indicated that hypomorphic mutants could be created by inserting cis-regulatory sequences composed ...
Geralle Powell +2 more
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Frontiers in Genetics, 2018 Objective: To explore the association between methadone dosage, plasma drug concentration, SNPs of μ-opioid receptor gene (OPRM1), ATP-binding cassette subfamily B member 1 gene (ABCB1), and methadone maintenance treatment (MMT) response.Method: A total ...
Haifeng Jiang, Jiang Du, Seungjoo Haam
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