Results 131 to 140 of about 7,162,706 (382)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

The shaping and functional consequences of the dosage effect landscape in multiple myeloma [PDF]

, 2013
Background: Multiple myeloma (MM) is a malignant proliferation of plasma B cells. Based on recurrent aneuploidy such as copy number alterations (CNAs), myeloma is divided into two subtypes with different CNA patterns and patient survival outcomes.
Avet-Loiseau, Hervé, Li, Cheng, Magrangeas, Florence, Minvielle, Stéphane, Munshi, Nikhil C, Samur, Mehmet K, Shah, Parantu K, Wang, Xujun   +7 more
core   +4 more sources

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients’ neurons

Human Molecular Genetics, 2013
The hereditary spastic paraplegias (HSPs) are a heterogeneous group of motorneuron diseases characterized by progressive spasticity and paresis of the lower limbs.
Steven Havlicek, Z. Kohl, Himanshu K. Mishra, I. Prots, E. Eberhardt, Naime Denguir, Holger Wend, Sonja Plötz, Leah F. Boyer, M. Marchetto, S. Aigner, H. Sticht, T. W. Groemer, U. Hehr, A. Lampert, U. Schlötzer-Schrehardt, J. Winkler, F. Gage, B. Winner   +18 more
semanticscholar   +1 more source

Caracterización del perfil quimiosensibilidad y del estado de ampliación génica de un panel de líneas celulares de origen tumoral pulmonar

Revista Colombiana de Biotecnología, 2013
Título en Ingles: Characterization of chemosensitivity profile and gene amplification status of a panel of lung cancer cell linesTítulo Corto: Amplificación génica y quimiosensibilidad en líneas celulares de cáncer de pulmónResumen: En este trabajo se ...
Sandra Johanna Morantes, Sandra Perdomo, Edward Fabián Carrillo, Fabio Aristizábal   +3 more
doaj  

Gene Dosage Experiments in Enterobacteriaceae Using Arabinose-regulated Promoters

Bio-Protocol, 2017
This protocol is used to assay the effect of protein over-expression on fitness of E. coli. It is based on a plasmid expression of a protein of interest from an arabinose-regulated pBAD promoter followed by the measurement of the intracellular protein ...
Sanchari Bhattacharyya, Shimon Bershtein, Eugene I Shakhnovich   +2 more
doaj   +1 more source

Sexual Dimorphism of Body Size Is Controlled by Dosage of the X-Chromosomal Gene Myc and by the Sex-Determining Gene tra in Drosophila

Genetics, 2017
Drosophila females are larger than males. In this article, we describe how X-chromosome dosage drives sexual dimorphism of body size... Drosophila females are larger than males.
Kristina Wehr Mathews, Margrith Cavegn, M. Zwicky   +2 more
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Incomplete sex chromosome dosage compensation in the Indian meal moth, Plodia interpunctella, based on de novo transcriptome assembly. [PDF]

, 2016
Journal ArticleResearch Support, Non-U.S. Gov'tMales and females experience differences in gene dose for loci in the nonrecombining region of heteromorphic sex chromosomes. If not compensated, this leads to expression imbalances, with the homogametic sex
Harrison, PW, Mank, JE, Wedell, Nina
core   +1 more source

Further support for aneuploidy tolerance in wild yeast and effects of dosage compensation on gene copy-number evolution

eLife, 2016
In our prior work by Hose et al., we performed a genome-sequencing survey and reported that aneuploidy was frequently observed in wild strains of S. cerevisiae. We also profiled transcriptome abundance in naturally aneuploid isolates compared to isogenic
A. Gasch, James Hose, M. Newton, Maria Sardi, Mun Yong, Zhishi Wang   +5 more
semanticscholar   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source