Results 21 to 30 of about 7,162,706 (382)
Photoreactivation and Gene Dosage in Yeast [PDF]
Journal of Bacteriology, 1972 The amount of photoreactivating enzyme in tetraploid cells of Saccharomyces cerevisiae and the ability of the cells to be photoreactivated after ultraviolet irradiation are directly proportional to the number of genes per cell involved in the synthesis of photoreactivating enzyme.
Michael A. Resnick, Jane K. Setlow
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Dosage-sensitive genes in evolution and disease [PDF]
BMC Biology, 2017 For a subset of genes in our genome a change in gene dosage, by duplication or deletion, causes a phenotypic effect. These dosage-sensitive genes may confer an advantage upon copy number change, but more typically they are associated with disease, including heart disease, cancers and neuropsychiatric disorders. This gene copy number sensitivity creates
Alan M. Rice, Aoife McLysaght
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Gene dosage analysis in Azotobacter vinelandii. [PDF]
Genetics, 1992 Abstract For more than a decade, Azotobacter vinelandii has been considered a polyploid bacterium on the basis of physical studies of chromosome size and DNA content per cell. However, as described in the present work, many genetic operations can be performed in A. vinelandii without the constraints expected in a polyploid bacterium: (i)
Maldonado Caro, Rafael Diego +3 more
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The Plant Cell, 2022 Gene duplications have long been recognized as a contributor to the evolution of genes with new functions. Multiple copies of genes can result from tandem duplication, from transposition to new chromosomes, or from whole-genome duplication (polyploidy ...
J. Birchler, Hua Yang
semanticscholar +1 more source
Gene Dosage by Quantitative Real-Time PCR
BioTechniques, 1999 J.-L. Boulay +5 more
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Distinct expression and methylation patterns for genes with different fates following a single whole-genome duplication in flowering plants [PDF]
, 2020 For most sequenced flowering plants, multiple whole-genome duplications (WGDs) are found. Duplicated genes following WGD often have different fates that can quickly disappear again, be retained for long(er) periods, or subsequently undergo small-scale ...
Chen, Jinming +10 more
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Disease Models & Mechanisms, 2021 Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions.
Leticia L. Niborski +12 more
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Does gene dosage really matter? [PDF]
Journal of Biology, 2007 Mechanisms to compensate for dosage differences of genes on sex chromosomes are widespread in animals and have been thought to be critical for viability. However, in birds, compensation is inefficient, implying that for many genes dosage compensation is not critical, and for some genes, dosage differences have even been selected for.
Graves, Jennifer, Disteche, Christine M
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Heteroduplex Formation in SMN Gene Dosage Analysis [PDF]
The Journal of Molecular Diagnostics, 2001 Most spinal muscular atrophy patients lack both copies of SMN1 exon 7 and most carriers have only one copy of SMN1 exon 7. We investigated the effect of SMN1/SMN2 heteroduplex formation on SMN gene dosage analysis, which is an assay to determine copy number of SMN1 exon 7 that utilizes multiplex quantitative polymerase chain reaction (PCR) with DraI ...
Shuji Ogino +4 more
openalex +5 more sources
On the Mode of Gene-Dosage Compensation in Drosophila [PDF]
Genetics, 1997 A procedure is described for determining the mode and magnitude of gene-dosage compensation of transformed genes. It involves measurement of the ratio of the activity of a gene inserted at X-linked sites to the activity of the same gene inserted at autosomal sites.
Matthew Meselson +2 more
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