Results 21 to 30 of about 7,614,096 (384)

The multiple fates of gene duplications: Deletion, hypofunctionalization, subfunctionalization, neofunctionalization, dosage balance constraints, and neutral variation

The Plant Cell, 2022
Gene duplications have long been recognized as a contributor to the evolution of genes with new functions. Multiple copies of genes can result from tandem duplication, from transposition to new chromosomes, or from whole-genome duplication (polyploidy ...
J. Birchler, Hua Yang
semanticscholar   +1 more source

Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease

Journal of Alzheimer's Disease, 2015
Bernhard Clemens Richard, Anastasiia Kurdakova, Sandra Baches, Thomas A. Bayer, Sascha Weggen, Oliver Wirths   +5 more
openalex   +3 more sources

Gene Dosage by Quantitative Real-Time PCR

BioTechniques, 1999
J.-L. Boulay, J. Reuter, R. Ritschard, L. Terracciano, R. Herrmann, C. Rochlitz   +5 more
doaj   +3 more sources

Genomic variants affecting homoeologous gene expression dosage contribute to agronomic trait variation in allopolyploid wheat

Nature Communications, 2022
Allopolyploidy greatly expands the range of possible regulatory interactions among functionally redundant homoeologous genes. However, connection between the emerging regulatory complexity and expression and phenotypic diversity in polyploid crops ...
Fei He, Wei Wang, W. Rutter, K. Jordan, Jie Ren, Ella Taagen, N. DeWitt, D. Sehgal, S. Sukumaran, S. Dreisigacker, Matthew Reynolds, J. Halder, S. Sehgal, Shuyu Liu, Jianli Chen, A. Fritz, J. Cook, G. Brown-Guedira, M. Pumphrey, A. Carter, M. Sorrells, J. Dubcovsky, M. Hayden, Alina Akhunova, P. Morrell, L. Szabo, M. Rouse, E. Akhunov   +27 more
semanticscholar   +1 more source

Photoreactivation and Gene Dosage in Yeast [PDF]

Journal of Bacteriology, 1972
The amount of photoreactivating enzyme in tetraploid cells of Saccharomyces cerevisiae and the ability of the cells to be photoreactivated after ultraviolet irradiation are directly proportional to the number of genes per cell involved in the synthesis of photoreactivating enzyme.
M A, Resnick, J K, Setlow
openaire   +2 more sources

Identificación de portadoras de distrofia muscular de Duchenne y Becker (DMD/DMB) mediante análisis de dosis génica y polimorfismos de ADN

Biomédica: revista del Instituto Nacional de Salud, 2000
Se identificaron 7 mujeres portadoras y 15 no portadoras de deleción en 16 familias con distrofia muscular de Duchenne o de Becker (DMDIDMB) mediante PCR multiplex cuantitativa y análisis de dosis génica. Los afectados con DMDIDMB mostraron deleciones en
Patricia Hernández, Yenny M. Gómez, Carlos M. Restrepo   +2 more
doaj   +1 more source

Gene dosage analysis in Azotobacter vinelandii. [PDF]

Genetics, 1992
Abstract For more than a decade, Azotobacter vinelandii has been considered a polyploid bacterium on the basis of physical studies of chromosome size and DNA content per cell. However, as described in the present work, many genetic operations can be performed in A. vinelandii without the constraints expected in a polyploid bacterium: (i)
Maldonado Caro, Rafael Diego, Garzón Villar, Andrés, Dean, Dennis R., Casadesús Pursals, Josep   +3 more
openaire   +3 more sources

Gene duplicability of core genes is highly consistent across all angiosperms [PDF]

, 2016
Gene duplication is an important mechanism for adding to genomic novelty. Hence, which genes undergo duplication and are preserved following duplication is an important question. It has been observed that gene duplicability, or the ability of genes to be
De Smet, Riet, Defoort, Jonas, Li, Zhen, Maere, Steven, Tasdighian, Setareh, Van de Peer, Yves   +5 more
core   +4 more sources

When the balance is broken: X‐linked gene dosage from two X chromosomes and female‐biased autoimmunity

Journal of Leukocyte Biology, 2019
Women and men exhibit differences in innate and adaptive immunity, and women are more susceptible to numerous autoimmune disorders. Two or more X chromosomes increases the risk for some autoimmune diseases, and increased expression of some X‐linked ...
C. Syrett, M. Anguera
semanticscholar   +1 more source

DNA Methylation Rebalances Gene Dosage after Mammalian Gene Duplications [PDF]

Molecular Biology and Evolution, 2011
Although gene duplication plays a major role in organismal evolution, it may also lead to gene dosage imbalance, thereby having an immediate adverse effect on an organism's fitness. Investigating the evolution of the expression patterns of genes that duplicated after the divergence of rodents and primates, we confirm that adaptive evolution has been ...
Andrew Ying-Fei, Chang, Ben-Yang, Liao
openaire   +2 more sources