Results 31 to 40 of about 7,162,706 (382)
Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?
Cells, 2022 Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to maintain the correct chromosome content over generations.
Narendra Kumar Chunduri +2 more
doaj +1 more source
Clinical Chemistry, 1998 Numerous investigations (both clinical and basic) in today’s molecular biology laboratory require accurate quantification of DNA by the polymerase chain reaction (PCR). To name a few important examples, quantitative PCR has been used to quantify viral copy number, to perform gene expression studies, and to diagnose genetic diseases.
openaire +2 more sources
Biomédica: revista del Instituto Nacional de Salud, 2000 Se identificaron 7 mujeres portadoras y 15 no portadoras de deleción en 16 familias con distrofia muscular de Duchenne o de Becker (DMDIDMB) mediante PCR multiplex cuantitativa y análisis de dosis génica. Los afectados con DMDIDMB mostraron deleciones en
Patricia Hernández +2 more
doaj +1 more source
Dosage compensation in birds [PDF]
, 2001 The Z and W sex chromosomes of birds have evolved independently from the mammalian X and Y chromosomes [1]. Unlike mammals, female birds are heterogametic (ZW), while males are homogametic (ZZ).
Bird, A P +4 more
core +1 more source
Karyotype, ploidy, and gene dosage [PDF]
WormBook, 2005 The normal karyotype of Caenorhabditis elegans, with its five pairs of autosomes and single pair of X chromosomes, is described. General features of chromosomes and global differences between different chromosomal regions are discussed. Abnormal karyotypes, including duplications, deficiencies, inversions, translocations and chromosome fusions are ...
openaire +2 more sources
Indonesian Journal of Chemistry, 2019 This study assessed the combinations of genetic manipulation; signal peptide modification, gene dosage increment and co-expression of folding component, to increase Saccharomycopsis fibuligera R64 α-amylase (Sfamy) secretion in Pichia pastoris.
Shabarni Gaffar +4 more
doaj +1 more source
Gene duplicability of core genes is highly consistent across all angiosperms [PDF]
, 2016 Gene duplication is an important mechanism for adding to genomic novelty. Hence, which genes undergo duplication and are preserved following duplication is an important question. It has been observed that gene duplicability, or the ability of genes to be
De Smet, Riet +5 more
core +4 more sources
Journal of Leukocyte Biology, 2019 Women and men exhibit differences in innate and adaptive immunity, and women are more susceptible to numerous autoimmune disorders. Two or more X chromosomes increases the risk for some autoimmune diseases, and increased expression of some X‐linked ...
C. Syrett, M. Anguera
semanticscholar +1 more source
Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1) [PDF]
, 2018 VEGF signaling through its tyrosine kinase receptor, VEGFR2 (FLK1), is critical for tumor angiogenesis. Previous studies have identified a critical gene dosage effect of VegfA in embryonic development and vessel homeostasis, neovascularization, and tumor
Choi, Kyunghee +4 more
core +3 more sources
Selective gene dosage by CRISPR‐Cas9 genome editing in hexaploid Camelina sativa
Plant Biotechnology Journal, 2017 In many plant species, gene dosage is an important cause of phenotype variation. Engineering gene dosage, particularly in polyploid genomes, would provide an efficient tool for plant breeding.
Céline Morineau +6 more
semanticscholar +1 more source