Results 31 to 40 of about 7,614,096 (384)

Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]

, 2010
In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S., Flynn, Kenneth M., Hatcher, Philip J., Vohr, Samuel H.   +3 more
core   +2 more sources

Selective gene dosage by CRISPR‐Cas9 genome editing in hexaploid Camelina sativa

Plant Biotechnology Journal, 2017
In many plant species, gene dosage is an important cause of phenotype variation. Engineering gene dosage, particularly in polyploid genomes, would provide an efficient tool for plant breeding.
Céline Morineau, Y. Bellec, Frédérique Tellier, L. Gissot, Z. Kelemen, F. Nogué, J. Faure   +6 more
semanticscholar   +1 more source

Combination of Genetic Manipulation Improved Saccharomycopsis fibuligera α-Amylase Secretion by Pichia pastoris

Indonesian Journal of Chemistry, 2019
This study assessed the combinations of genetic manipulation; signal peptide modification, gene dosage increment and co-expression of folding component, to increase Saccharomycopsis fibuligera R64 α-amylase (Sfamy) secretion in Pichia pastoris.
Shabarni Gaffar, Dessy Natalia, Toto Subroto, Oo Suprijana, Soetijoso Soemitro   +4 more
doaj   +1 more source

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Disease Models & Mechanisms, 2021
Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions.
Leticia L. Niborski, Mélanie Paces-Fessy, Pierbruno Ricci, Adeline Bourgeois, Pedro Magalhães, Maria Kuzma-Kuzniarska, Celine Lesaulnier, Martin Reczko, Edwige Declercq, Petra Zürbig, Alain Doucet, Muriel Umbhauer, Silvia Cereghini   +12 more
doaj   +1 more source

Down syndrome-recent progress and future prospects [PDF]

, 2009
Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia.
Adams, Adayev, Ahn, Ait Yahya-Graison, Altafaj, Antonarakis, Arron, Aylward, Aylward, Bartel, Belichenko, Bercovich, Best, Bliss, Brault, Canfield, Canzonetta, Carothers, Clark, Contestabile, Costa, de Graaf, De Vita, Denoeud, Dowjat, Draheim, E. M.C. Fisher, Ermak, Ermak, F. K. Wiseman, Fernandez, Freeman, Fuentes, Gerstein, Glasson, Granholm, Granholm, Groet, Guidi, Gwack, Harashima, Hasle, Hassold, Hill, Holland, Holtzman, Holtzman, Hunter, Hunter, Izraeli, Janicki, Johannsen, K. A. Alford, Kiyoi, Klusmann, Kuhn, Lai, Lee, Liang, Loos, Lorenzi, Mart  nez de Lagr  n, Maslen, Meng, Moore, Morice, Morris, Morrison, Murthy, Necchi, Nistor, O'Doherty, O'Donovan, O'Nuallain, Olson, Park, Pearlson, Prandini, Richtsmeier, Ryoo, Sato, Seo, Sethupathy, Stefansson, Sultan, Sussan, Toso, Tybulewicz, V. L.J. Tybulewicz, Wahab, Walters, Wechsler, Wegiel, Weis, Williams, Woods, Yang   +96 more
core   +2 more sources

Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?

Cells, 2022
Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to maintain the correct chromosome content over generations.
Narendra Kumar Chunduri, Karen Barthel, Zuzana Storchova   +2 more
doaj   +1 more source

Partial dosage compensation in Strepsiptera, a sister group of beetles. [PDF]

, 2015
Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Bachtrog, Doris, Mahajan, Shivani
core   +2 more sources

A comprehensive genomic scan reveals gene dosage balance impacts on quantitative traits in Populus trees

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Phenotypic trait variation can be linked to genomic sequence variation. These differences range from a single nucleotide to larger insertion and deletion (indel) of chromosomal segments.
H. Bastiaanse, Matthew S. Zinkgraf, C. Canning, Helen Tsai, Meric C Lieberman, L. Comai, I. Henry, A. Groover   +7 more
semanticscholar   +1 more source

Determining Gene Dosage [PDF]

Clinical Chemistry, 1998
Numerous investigations (both clinical and basic) in today’s molecular biology laboratory require accurate quantification of DNA by the polymerase chain reaction (PCR). To name a few important examples, quantitative PCR has been used to quantify viral copy number, to perform gene expression studies, and to diagnose genetic diseases.
openaire   +1 more source

Does gene dosage really matter? [PDF]

Journal of Biology, 2007
Mechanisms to compensate for dosage differences of genes on sex chromosomes are widespread in animals and have been thought to be critical for viability. However, in birds, compensation is inefficient, implying that for many genes dosage compensation is not critical, and for some genes, dosage differences have even been selected for.
Graves, Jennifer, Disteche, Christine M
openaire   +3 more sources