Results 41 to 50 of about 7,162,706 (382)
Genetic Analysis of RAB39B in an Early-Onset Parkinson's Disease Cohort
Frontiers in Neurology, 2020 Pathogenic variants in the gene encoding RAB39B, resulting in the loss of protein function, lead to the development of X-linked early-onset parkinsonism.
Yujing Gao +10 more
doaj +1 more source
Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]
, 2010 In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S. +3 more
core +2 more sources
FOXG1 Dose in Brain Development
Frontiers in Pediatrics, 2019 Brain development is a highly regulated process that involves the precise spatio-temporal activation of cell signaling cues. Transcription factors play an integral role in this process by relaying information from external signaling cues to the genome ...
Nuwan C. Hettige +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Phenotypic trait variation can be linked to genomic sequence variation. These differences range from a single nucleotide to larger insertion and deletion (indel) of chromosomal segments.
H. Bastiaanse +7 more
semanticscholar +1 more source
Adipose Is a Conserved Dosage-Sensitive Antiobesity Gene [PDF]
Cell Metabolism, 2007 Adipose (Adp) is an evolutionarily conserved gene isolated from naturally occurring obese flies homozygous for an adp mutation. Here we show that the anti-obesity function of Adp (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms to mammals. Further, Adp appears to inhibit fat formation in a dosage-sensitive manner.
Suh, JM Suh, Jae Myoung +7 more
openaire +4 more sources
Loss of unstably amplified dihydrofolate reductase genes from mouse cells is greatly accelerated by hydroxyurea [PDF]
, 1983 Previous work has shown that mammalian cells that carry unstably amplified genes for dihydrofolate reductase (DHFR) gradually lose the amplified DHFR genes when grown in the absence of the DHFR inhibitor methotrexate (MTX). Unstably amplified genes occur
Snapka, Robert M., Varshavsky, Alexander
core +1 more source
Targeting determinants of dosage compensation in Drosophila [PDF]
, 2006 The dosage compensation complex (DCC) in Drosophila melanogaster is responsible for up-regulating transcription from the single male X chromosome to equal the transcription from the two X chromosomes in females.
Gregor D Gilfillan +5 more
core +7 more sources
Rambam Maimonides Medical Journal, 2011 Genetic determinants of sex in placental mammals developed by the evolution of primordial autosomes into the male and female sex chromosomes. The Y chromosome determines maleness by the action of the gene SRY, which encodes a protein that initiates a ...
Sophia Balderman, Marshall A. Lichtman
doaj +1 more source
Partial dosage compensation in Strepsiptera, a sister group of beetles. [PDF]
, 2015 Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation,
Bachtrog, Doris, Mahajan, Shivani
core +2 more sources
Accelerating pathway evolution by increasing the gene dosage of chromosomal segments
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Gene duplication and divergence are cornerstones of evolution. Genetic redundancy resulting from repeated DNA provides flexibility for transient changes in copy number that may confer selective benefit under new or changing environmental ...
Melissa P. Tumen-Velasquez +11 more
semanticscholar +1 more source