Results 61 to 70 of about 7,162,706 (382)
Human gene copy number spectra analysis in congenital heart malformations [PDF]
, 2012 The clinical significance of copy number variants (CNVs) in congenital heart disease (CHD) continues to be a challenge. Although CNVs including genes can confer disease risk, relationships between gene dosage and phenotype are still being defined.
Bick, David P. +13 more
core +2 more sources
Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity
bioRxiv, 2016 Several genes exhibit gene dosage toxicity yet its molecular underpinnings remain unknown. Here we demonstrate that overexpression of DHFR in E. coli causes toxic metabolic imbalance triggered by interactions with several enzymes involved in 1-carbon ...
Sanchari Bhattacharyya +6 more
semanticscholar +1 more source
Noncoding RNA Genes in Dosage Compensation and Imprinting [PDF]
Cell, 2000 Alleles silenced via imprinting are not thought to be packaged in densely compacted heterochromatin, but several imprinted genes have oppositely imprinted noncoding RNA partners nearby on the chromosome. Maternal expression of the Igf2r gene is reminiscent of the Xist/Tsix locus in that imprinting is tied to antisense transcription on the paternal ...
Mitzi I. Kuroda +2 more
openaire +3 more sources
Annual Review of Genetics, 2016 The complex manner in which organisms respond to changes in their gene dosage has long fascinated geneticists. Oddly, although the existence of dominance implies that dosage reductions often have mild phenotypes, extra copies of whole chromosomes ...
J. Pires, G. Conant
semanticscholar +1 more source
Dosage Compensation of Sex Chromosome Genes in Eukaryotes [PDF]
Acta Naturae, 2010 Sex chromosome evolution is accompanied by significant divergence in morphology and gene content and results in most genes of one of the sex chromosomes being present in two dosages in one sex and in one dosage in the other. To eliminate the difference in the expression levels of these genes between sexes and to restore equal expression levels of the ...
Dementyeva, E., Zakian, S.
openaire +4 more sources
Compensation of Dosage-Sensitive Genes on the Chicken Z Chromosome. [PDF]
, 2016 In many diploid species, sex determination is linked to a pair of sex chromosomes that evolved from a pair of autosomes. In these organisms, the degeneration of the sex-limited Y or W chromosome causes a reduction in gene dose in the heterogametic sex ...
Dessimoz, C. +3 more
core +2 more sources
New Phytologist, 2016 Retention or loss of paralogs following duplication correlates strongly with the function of the gene and whether the gene was duplicated by whole-genome duplication (WGD) or by small-scale duplication.
J. Coate +3 more
semanticscholar +1 more source
Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont
mSystems, 2017 Secondary metabolites, which are small-molecule organic compounds produced by living organisms, provide or inspire drugs for many different diseases.
J. Lopera +3 more
semanticscholar +1 more source
BMC Genomics, 2022 Background Mammalian sex chromosomes provide dosage compensation, but avian lack a global mechanism of dose compensation. Herein, we employed nanopore sequencing to investigate the genetic basis of gene expression and gene dosage effects in avian Z ...
Jianmei Wang +9 more
doaj +1 more source
Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]
, 2015 The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R +4 more
core +1 more source