Results 1 to 10 of about 485,642 (195)
The challenge of measuring mosquito flight performance: going beyond sterile insect technique and into transgenic and gene drive-based approaches [PDF]
Open BiologyInvasive insects inflict global costs of more than 70 billion USD annually by destroying crops and spreading disease-causing pathogens. Sterile insect technique (SIT), an insect population control method, involves the irradiation or chemical ...
Paola Najera +4 more
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Gene Drive: Evolved and Synthetic [PDF]
ACS Chemical Biology, 2018 Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to-or indeed even if they detract from-organismal survival and reproduction. Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing ...
Austin Burt, Andrea Crisanti
openalex +5 more sources
Driving down malaria transmission with engineered gene drives
Frontiers in Genetics, 2022 The last century has witnessed the introduction, establishment and expansion of mosquito-borne diseases into diverse new geographic ranges. Malaria is transmitted by female Anopheles mosquitoes.
William T. Garrood +5 more
doaj +5 more sources
Gene drives : Beleidssignalering
, 2016 Gene drives zijn genetische eigenschappen die zodanig in het DNA van een organisme zijn ingebouwd dat ze aan alle nakomelingen worden doorgegeven, in plaats van aan een deel. Dit werkt ook door in de volgende generaties. Vooral als organismen zich snel voortplanten, kan deze eigenschap zich snel en blijvend in een hele populatie van een organisme ...
J Westra +4 more
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The suppressive potential of a gene drive in populations of invasive social wasps is currently limited. [PDF]
Sci Rep, 2023 Meiborg AB +4 more
europepmc +3 more sources
Molecular Therapy: Methods & Clinical Development, 2022 Duchenne muscular dystrophy (DMD) is typically caused by mutations that disrupt the DMD reading frame, but nonsense mutations in the 5′ part of the gene induce utilization of an internal ribosomal entry site (IRES) in exon 5, driving expression of a ...
Nicolas Wein +12 more
doaj +1 more source
Making gene drive biodegradable [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020 Gene drive systems have long been sought to modify mosquito populations and thus combat malaria and dengue. Powerful gene drive systems have been developed in laboratory experiments, but may never be used in practice unless they can be shown to be acceptable through rigorous field-based testing. Such testing is complicated by the anticipated difficulty
Josef Zapletal +5 more
openaire +2 more sources
Molecular Therapy: Methods & Clinical Development, 2021 The increasing demand for adeno-associated virus (AAV) vectors, a result from the surging interest for their potential to cure human genetic diseases by gene transfer, tumbled on low-performing production systems. Innovative improvements to increase both
Chenghui Yu +8 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 Facioscapulohumeral muscular dystrophy (FSHD) arises from epigenetic changes that de-repress the DUX4 gene in muscle. The full-length DUX4 protein causes cell death and muscle toxicity, and therefore we hypothesize that FSHD therapies should center on ...
Afrooz Rashnonejad +4 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 In a phase 1/2, open-label dose escalation trial, we delivered rAAVrh74.MCK.GALGT2 (also B4GALNT2) bilaterally to the legs of two boys with Duchenne muscular dystrophy using intravascular limb infusion.
Kevin M. Flanigan +14 more
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