Results 31 to 40 of about 1,021,897 (307)
Circumventing antivector immunity: potential use of nonhuman adenoviral vectors [PDF]
, 2014 Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase
Beard C.W. +30 more
core +3 more sources
The principles driving gene drives for conservation
Environmental Science & Policy, 2022 This is the final version. Available on open access from Elsevier via the DOI in this record ; Gene drive technology is an emerging biotechnology with the potential to address some of the most intractable global biodiversity conservation issues. Scientists are exploring potential gene drive applications for managing invasive species and building ...
Hartley, S, Taitingfong, R, Fidelman, P
openaire +2 more sources
Genetic Approaches for Controlling CRISPR-based Autonomous Homing Gene Drives
Frontiers in Bioengineering and Biotechnology, 2022 CRISPR-based autonomous homing gene drives are a potentially transformative technology with the power to reduce the prevalence of, or even eliminate, vector-borne diseases, agricultural pests, and invasive species.
Pratima R. Chennuri +2 more
doaj +1 more source
Evolution of substrate specificity in a retained enzyme driven by gene loss. [PDF]
, 2017 The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that ...
Babnigg, Gyorgy +14 more
core +1 more source
Gene drive: progress and prospects [PDF]
Proceedings of the Royal Society B: Biological Sciences, 2019 Gene drive is a naturally occurring phenomenon in which selfish genetic elements manipulate gametogenesis and reproduction to increase their own transmission to the next generation. Currently, there is great excitement about the potential of harnessing such systems to control major pest and vector populations.
Wedell, N, Price, T A R, Lindholm, A K
openaire +4 more sources
Ecology and Evolution, 2020 Selfish genetic elements have been found in the genomes of many species, yet our understanding of their evolutionary dynamics is only partially understood.
Sarah A. Cash +3 more
doaj +1 more source
Benefits and risks of gene drives for invasive plant management - the case for common tansy
Frontiers in Agronomy, 2023 Invasive plants cause significant environmental and economic damage, but land managers have few control options. Common tansy (Tanacetum vulgare) is prevalent in many US states and is one of the most reported invasive plants in Minnesota.
Lori Croghan +4 more
doaj +1 more source
Promoter trapping in microalgae using the antibiotic paromomycin as selective agent [PDF]
, 2012 The lack of highly active endogenous promoters to drive the expression of transgenes is one of the main drawbacks to achieving efficient transformation of many microalgal species.
Díaz Santos, Encarnación +5 more
core +3 more sources
Chapter 9 Gene Drive Strategies for Population Replacement [PDF]
, 2016 Gene drive systems are selfish genetic elements capable of spreading into a population despite a fitness cost. A variety of these systems have been proposed for spreading disease-refractory genes into mosquito populations, thus reducing their ability to ...
Akbari, Omar S, Marshall, John M
core +1 more source
Efficient allelic-drive in Drosophila. [PDF]
, 2019 Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single ...
Berni, Mateus +9 more
core +3 more sources