Results 41 to 50 of about 1,021,897 (307)

Controlling invasive rodents via synthetic gene drive and the role of polyandry [PDF]

, 2019
House mice are a major ecosystem pest, particularly threatening island ecosystems as a non-native invasive species. Rapid advances in synthetic biology offer new avenues to control pest species for biodiversity conservation.
Blondel, Dimitri V., Cornell, Stephen J., Godwin, John, Manser, Andri, Price, Tom A. R., Serr, Megan, Sutter, Andreas   +6 more
core   +1 more source

Author Correction: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Nature Communications, 2018
The original version of this Article contained an error in the spelling of the author Jonah B Sacha, which was incorrectly given as Jonah Sacha. These errors have now been corrected in both the PDF and HTML versions of the Article.
Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O’Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B. Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie   +19 more
doaj   +1 more source

Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding

Nature Communications, 2018
Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8+ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding ...
Lucy C. Walters, Karl Harlos, Simon Brackenridge, Daniel Rozbesky, Jordan R. Barrett, Vitul Jain, Thomas S. Walter, Chris A. O’Callaghan, Persephone Borrow, Mireille Toebes, Scott G. Hansen, Jonah B Sacha, Shaheed Abdulhaqq, Justin M. Greene, Klaus Früh, Emily Marshall, Louis J. Picker, E. Yvonne Jones, Andrew J. McMichael, Geraldine M. Gillespie   +19 more
doaj   +1 more source

Evaluation of Hydrogen Peroxide Fumigation and Heat Treatment for Standard Emergency Arthropod Inactivation in BSL-3 Insectaries

Frontiers in Bioengineering and Biotechnology, 2020
Climate change and global movements of people and goods have accelerated the spread of invasive species, including insects that vector infectious diseases, which threaten the health of more than half of the world’s population. Increasing research efforts
Irina Häcker, Irina Häcker, Roland Koller, Gerrit Eichner, Jakob Martin, Eleni Liapi, Johanna Rühl, Tanja Rehling, Marc F. Schetelig, Marc F. Schetelig   +9 more
doaj   +1 more source

Gene drive strategies of pest control in agricultural systems: Challenges and opportunities

Evolutionary Applications, 2021
Recent advances in gene‐editing technologies have opened new avenues for genetic pest control strategies, in particular around the use of gene drives to suppress or modify pest populations. Significant uncertainty, however, surrounds the applicability of
Mathieu Legros, John M. Marshall, Sarina Macfadyen, Keith R. Hayes, Andy Sheppard, Luke G. Barrett   +5 more
doaj   +1 more source

Spatial gene drives and pushed genetic waves

, 2017
Gene drives have the potential to rapidly replace a harmful wild-type allele with a gene drive allele engineered to have desired functionalities. However, an accidental or premature release of a gene drive construct to the natural environment could ...
Nelson, David R., Stone, Howard A., Tanaka, Hidenori   +2 more
core   +1 more source

Inverse Medea as a Novel Gene Drive System for Local Population Replacement: A Theoretical Analysis [PDF]

, 2011
One strategy to control mosquito-borne diseases, such as malaria and dengue fever, on a regional scale is to use gene drive systems to spread disease-refractory genes into wild mosquito populations.
Alphey, B. A. Hay, Chen, Corby-Harris, Davis, Gould, Huh, Ito, J. M. Marshall, Marshall, Marshall, Robinson, Wang, Yoo   +13 more
core   +2 more sources

Molecular safeguarding of CRISPR gene drive experiments

eLife, 2019
CRISPR-based homing gene drives have sparked both enthusiasm and deep concerns due to their potential for genetically altering entire species. This raises the question about our ability to prevent the unintended spread of such drives from the laboratory ...
Jackson Champer, Joan Chung, Yoo Lim Lee, Chen Liu, Emily Yang, Zhaoxin Wen, Andrew G Clark, Philipp W Messer   +7 more
doaj   +1 more source

In Our Image: The Ethics of CRISPR Genome Editing

Biomolecular Concepts, 2021
The advent of genome editing technology promises to transform human health, livestock and agriculture, and to eradicate pest species. This transformative power demands urgent scrutiny and resolution of the ethical conflicts attached to the creation and ...
Eissenberg Joel C.
doaj   +1 more source

Competition and boundary formation in heterogeneous media: Application to neuronal differentiation [PDF]

, 2014
We analyze an inhomogeneous system of coupled reaction-diffusion equations representing the dynamics of gene expression during differentiation of nerve cells. The outcome of this developmental phase is the formation of distinct functional areas separated
Perthame, Benoit, Quiñinao, Cristobal, Touboul, Jonathan   +2 more
core   +6 more sources