Results 51 to 60 of about 1,021,897 (307)
Gene Loss Predictably Drives Evolutionary Adaptation [PDF]
Molecular Biology and Evolution, 2020 Abstract Loss of gene function is common throughout evolution, even though it often leads to reduced fitness. In this study, we systematically evaluated how an organism adapts after deleting genes that are important for growth under oxidative stress.
Helsen, Jana +6 more
openaire +3 more sources
CRISPR-based genetic control strategies for insect pests
Journal of Integrative Agriculture, 2023 Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in ...
Ying YAN +3 more
doaj +1 more source
Evolutionary Applications, 2019 Optimism regarding potential epidemiological and conservation applications of modern gene drives is tempered by concern about the possibility of unintended spread of engineered organisms beyond the target population. In response, several novel gene drive
Sumit Dhole, Alun L. Lloyd, Fred Gould
doaj +1 more source
Isolating intrinsic noise sources in a stochastic genetic switch [PDF]
, 2011 The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to
Newby, J. M.
core +2 more sources
A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. [PDF]
, 2019 Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage.
Bier, Ethan +3 more
core +1 more source
The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity [PDF]
, 2016 Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), produce reactive oxygen species (ROS) that perform a wide range of functions.
Antonio Molina +6 more
core +1 more source
Lethal Gene Drive Selects Inbreeding [PDF]
, 2016 AbstractThe use of ‘selfish’ gene drive systems to suppress or even extinguish populations has been proposed on theoretical grounds for almost half a century. Creating these genes has recently become possible with CRISPR technology. One seemingly feasible approach, originally proposed by Burt, is to create a homing endonuclease gene (HEG) that inserts ...
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis +13 more
wiley +1 more source
Combinations of Spok genes create multiple meiotic drivers in Podospora
eLife, 2019 Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi.
Aaron A Vogan +10 more
doaj +1 more source
Annals of Medicine, 2023 Background: In the era of insecticides and anti-malarial drug resistance, gene drive technology holds considerable promise for malaria control. Gene drive technology deploys genetic modifications into mosquito populations to impede their ability to ...
Yusuf Amuda Tajudeen +7 more
doaj +1 more source