Gene Loss Predictably Drives Evolutionary Adaptation [PDF]
Molecular Biology and Evolution, 2020 Abstract Loss of gene function is common throughout evolution, even though it often leads to reduced fitness. In this study, we systematically evaluated how an organism adapts after deleting genes that are important for growth under oxidative stress.
Helsen, Jana +6 more
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Isolation and characterization of strong gene regulatory sequences from apple, Malus x domestica [PDF]
, 2011 For the strong expression of genes in plant tissue, the availability of specific gene regulatory sequences is desired. We cloned promoter and terminator sequences of an apple (Malus x domestica) ribulose biphosphate carboxylase small subunit gene (MdRbcS)
Krens, F.A. +2 more
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Evolutionary Applications, 2019 Optimism regarding potential epidemiological and conservation applications of modern gene drives is tempered by concern about the possibility of unintended spread of engineered organisms beyond the target population. In response, several novel gene drive
Sumit Dhole, Alun L. Lloyd, Fred Gould
doaj +1 more source
CRISPR-based genetic control strategies for insect pests
Journal of Integrative Agriculture, 2023 Genetic control strategies such as the sterile insect technique have successfully fought insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic repeats) technology, together with high-quality genomic resources obtained in ...
Ying YAN +3 more
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The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma [PDF]
, 2016 The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, levels of the initiator methionine tRNA (tRNAiMet) in stromal fibroblasts have been shown to influence extracellular matrix (ECM) secretion to drive tumour growth and ...
Birch, Joanna +11 more
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Mutational analysis of the gene start sequences of pneumonia virus of mice [PDF]
, 2007 The transcriptional start sequence of pneumonia virus of mice is more variable than that of the other pneumoviruses, with five different nine-base gene start (GS) sequences found in the PVM genome.
Dibben, Oliver +1 more
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Combinations of Spok genes create multiple meiotic drivers in Podospora
eLife, 2019 Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi.
Aaron A Vogan +10 more
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Lethal Gene Drive Selects Inbreeding [PDF]
, 2016 AbstractThe use of ‘selfish’ gene drive systems to suppress or even extinguish populations has been proposed on theoretical grounds for almost half a century. Creating these genes has recently become possible with CRISPR technology. One seemingly feasible approach, originally proposed by Burt, is to create a homing endonuclease gene (HEG) that inserts ...
openaire +2 more sources
A bacterial gene-drive system efficiently edits and inactivates a high copy number antibiotic resistance locus. [PDF]
, 2019 Gene-drive systems in diploid organisms bias the inheritance of one allele over another. CRISPR-based gene-drive expresses a guide RNA (gRNA) into the genome at the site where the gRNA directs Cas9-mediated cleavage.
Bier, Ethan +3 more
core +1 more source
The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity [PDF]
, 2016 Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), produce reactive oxygen species (ROS) that perform a wide range of functions.
Antonio Molina +6 more
core +1 more source