Results 91 to 100 of about 318,177 (248)
Scientific Reports, 2022 The glutathione S-transferases (GST) genes are a multigene family of enzymes involved in the metabolism of endogenous and xenobiotic compounds by catalysing the conjugation of the reduced form of glutathione to the substrate.
Cherry L. Dykes +6 more
doaj +1 more source
The gain and loss of genes during 600 million years of vertebrate evolution [PDF]
, 2006 BACKGROUND: Gene duplication is assumed to have played a crucial role in the evolution of vertebrate organisms. Apart from a continuous mode of duplication, two or three whole genome duplication events have been proposed during the evolution of ...
Blomme, Tine +5 more
core +2 more sources
Duplicability of self-interacting human genes [PDF]
BMC Evolutionary Biology, 2010 Abstract Background There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model proposes that the evolution of new protein-protein interactions and protein complexes proceeds
Perez-Bercoff, Asa +2 more
openaire +6 more sources
BMC Biology, 2020 Background Gene duplication events play an important role in the evolution and adaptation of organisms. Duplicated genes can arise through different mechanisms, including whole-genome duplications (WGDs).
Dick Roelofs +7 more
doaj +1 more source
Two Major Paths of Gene-Duplicates Evolution [PDF]
arXiv, 2004 Evolving genomes increase a number of their genes by gene duplications. To escape degradation in a functionless pseudogene, any gene duplicate needs to be guarded by negative (purifying) selection from otherwise inevitable fixation of degenerative mutations. In the present study we focus on the evolutionary stage at which new duplicates come under such
arxiv
Simulating Evolution by Gene Duplication [PDF]
Genetics, 1987 ABSTRACT By considering the recent finding that unequal crossing over and other molecular interactions are contributing to the evolution of multigene families, a model of the origin of repetitive genes was studied by Monte Carlo simulations.
openaire +3 more sources
BMC Medical Genetics, 2018 Background Ornithine transcarbamylase deficiency (OTCD) is an X-linked recessive disorder involving a defect in the urea cycle caused by OTC gene mutations.
Katsuyuki Yokoi +5 more
doaj +1 more source
Reconciliation of Gene and Species Trees With Polytomies [PDF]
arXiv, 2012 Motivation: Millions of genes in the modern species belong to only thousands of `gene families'. A gene family includes instances of the same gene in different species (orthologs) and duplicate genes in the same species (paralogs). Genes are gained and lost during evolution.
arxiv
Molecular Cytogenetics, 2019 Background Complex chromosomal rearrangements are constitutive structural aberrations involving three or more breaks. They can be balanced or unbalanced and result in different outcomes, depending on deletion/duplication of genomic material, gene ...
Fabrizia Restaldi +11 more
doaj +1 more source
On the Evolutionary Fate of Mutant Allele at Duplicate Loci: a Theoretical and Simulation Study [PDF]
arXiv, 2010 Gene duplications are one of major primary driving forces for evolutionary novelty. We took population genetics models of genes duplicate to study how evolutionary forces acting during the fixation of mutant allele at duplicate loci. We study the fixation time of mutant allele at duplicate loci under double null recessive model (DNR) and ...
arxiv