Results 11 to 20 of about 172,476 (315)
Can Introns Stabilize Gene Duplication?
Biology, 2022 Gene duplication is considered one of the most important events that determine the evolution of genomes. However, the neo-duplication condition of a given gene is particularly unstable due to recombination events. Several mechanisms have been proposed to
Gioacchino Micheli, Giorgio Camilloni
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Promoter evolution of mammalian gene duplicates
BMC Biology, 2023 Background Gene duplication is thought to be a central process in evolution to gain new functions. The factors that dictate gene retention following duplication as well paralog gene divergence in sequence, expression and function have been extensively ...
Evgeny Fraimovitch, Tzachi Hagai
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Acquisition of new function through gene duplication in the metallocarboxypeptidase family
Scientific Reports, 2023 Gene duplication is a key first step in the process of expanding the functionality of a multigene family. In order to better understand the process of gene duplication and its role in the formation of new enzymes, we investigated recent duplication ...
Daniel Fajardo +2 more
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BMC Genomics, 2012 Background Gene duplication has had a major impact on genome evolution. Localized (or tandem) duplication resulting from unequal crossing over and whole genome duplication are believed to be the two dominant mechanisms contributing to vertebrate genome ...
Lu Jianguo +4 more
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Horizontal transfer, not duplication, drives the expansion of protein families in prokaryotes. [PDF]
PLoS Genetics, 2011 Gene duplication followed by neo- or sub-functionalization deeply impacts the evolution of protein families and is regarded as the main source of adaptive functional novelty in eukaryotes.
Todd J Treangen, Eduardo P C Rocha
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BMC Plant Biology, 2004 Background Most genes in Arabidopsis thaliana are members of gene families. How do the members of gene families arise, and how are gene family copy numbers maintained?
Baumgarten Andrew +4 more
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F1000Research, 2023 Gene content in genomes changes through several different processes, with gene duplication being an important contributor to such changes. Gene duplication occurs over a range of scales from individual genes to whole genomes, and the dynamics of this ...
Amanda E. Wilson +5 more
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Gene duplication and evolution in recurring polyploidization–diploidization cycles in plants
Genome Biology, 2019 Background The sharp increase of plant genome and transcriptome data provide valuable resources to investigate evolutionary consequences of gene duplication in a range of taxa, and unravel common principles underlying duplicate gene retention. Results We
Xin Qiao +7 more
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Copy-number changes in evolution: rates, fitness effects and adaptive significance
Frontiers in Genetics, 2013 Gene copy-number differences due to gene duplications and deletions are rampant in natural populations and play a crucial role in the evolution of genome complexity.
Vaishali eKatju, Ulfar eBergthorsson
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Parallel reorganization of protein function in the spindle checkpoint pathway through evolutionary paths in the fitness landscape that appear neutral in laboratory experiments. [PDF]
PLoS Genetics, 2017 Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution of ...
Alex N Nguyen Ba +5 more
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