Results 241 to 250 of about 6,833,475 (368)

Gene duplication and functional divergence of new genes contributed to the polar acclimation of Antarctic green algae. [PDF]

Mar Life Sci Technol, 2023
Zhang X, Han W, Fan X, Wang Y, Xu D, Sun K, Wang W, Zhang Y, Ma J, Ye N.   +9 more
europepmc   +1 more source

Increased expression in Escherichia coli of a synthetic gene encoding human somatomedin C after gene duplication and fusion

, 1987
M F Schulz, Gary Buell, E Schmid, Ramya Movva, Gerald Selzer   +4 more
openalex   +1 more source

Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). [PDF]

, 1994
Petr Jarolı́m, Hillard Rubin, S C Liu, Michael Cho, V Brabec, Laura H. Derick, S J Yi, Sara Teresinha Olalla Saad, Seth L. Alper, Carlo Brugnara   +9 more
openalex   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

Phylogenomic and Evolutionary Insights into Lipoprotein Lipase (LPL) Genes in Tambaqui: Gene Duplication, Tissue-Specific Expression and Physiological Implications. [PDF]

Genes (Basel)
Paixão RV, Bandeira IC, Reis VR, da Silva GF, Almeida O'Sullivan FL, Varela ES.   +5 more
europepmc   +1 more source

Left-Right Reversal Recurrently Evolved Regardless of Diaphanous-Related Formin Gene Duplication or Loss in Snails. [PDF]

J Mol Evol, 2023
Noda T, Satoh N, Gittenberger E, Asami T.   +3 more
europepmc   +1 more source

LEDGF Binds H3R17me2a Promoting De Novo Nucleotide Biosynthesis in SETD2 Mutant Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang, Yuhua Zhou, Yuezhou Zhang, Jing Lv, Yang Shen, Dong Zhang, Bo Liu, Wei Zhao, Junyi Ju, Qingyi Zhu, Ke Wang, Ninghan Feng   +11 more
wiley   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

The response to single-gene duplication implicates translation as a key vulnerability in aneuploid yeast. [PDF]

PLoS Genet
Dutcher HA, Hose J, Howe H, Rojas J, Gasch AP.   +4 more
europepmc   +1 more source

Role of riboflavin biosynthesis gene duplication and transporter in Aeromonas salmonicida virulence in marine teleost fish. [PDF]

Virulence, 2023
Gnanagobal H, Cao T, Hossain A, Vasquez I, Chakraborty S, Chukwu-Osazuwa J, Boyce D, Espinoza MJ, García-Angulo VA, Santander J.   +9 more
europepmc   +1 more source