Results 241 to 250 of about 7,215,457 (388)

Comparative genomics and expression analysis of polyamine oxidase gene family in Sorghum bicolor reveals functional specialization, gene duplication, and role in drought resilience. [PDF]

BMC Genomics
Ebeed HT.
europepmc   +1 more source

Double maternal effect: duplicated nucleoplasmin 2 genes,npm2aandnpm2b, are shared by fish and tetrapods, and have distinct and essential roles in early embryogenesis [PDF]

, 2017
Caroline Cheung, Jérémy Pasquier, Aurélien Bouleau, Thaovi Nguyen, Franck Chesnel, Yann Guiguen, Julien Bobe   +6 more
openalex   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Identification and Structural Characterization of a Novel COL3A1 Gene Duplication in a Family With Vascular Ehlers-Danlos Syndrome. [PDF]

Mol Genet Genomic Med
Miolo G, Machin P, De Conto M, Fortuna S, Viglio S, Della Puppa L, Geremia S, Corona G.   +7 more
europepmc   +1 more source

Venomous Noodles: The Evolution of Toxins in Nemertea through Positive Selection and Gene Duplication. [PDF]

Toxins (Basel), 2023
Sonoda GG, Tobaruela EC, Norenburg J, Fabi JP, Andrade SCS.   +4 more
europepmc   +1 more source

Human-specific duplicate genes: new frontiers for disease and evolution

, 2015
Alexander Nuttle
openalex   +1 more source

Additional file 2: of The birth of a human-specific neural gene by incomplete duplication and gene fusion

, 2017
Max L. Dougherty, Xander Nuttle, Osnat Penn, Bradley J. Nelson, John Huddleston, Carl Baker, Lana Harshman, Michael Duyzend, Mario Ventura, Francesca Antonacci, Richard Sandstrom, Megan Y. Dennis, Evan E. Eichler   +12 more
openalex   +1 more source

Duplications of histidine transport genes in Salmonella typhimurium and their use for the selection of deletion mutants [PDF]

, 1978
G F Ames, D. Biek, Elena N. Spudich
openalex   +1 more source

TBK1 gene duplication and normal-tension glaucoma.

JAMA ophthalmology, 2014
R. Ritch, B. Darbro, G. Menon, Cheryl L Khanna, Frances Solivan-Timpe, Ben R. Roos, Mansoor Sarfarzi, K. Kawase, Tetsuya Yamamoto, A. Robin, A. Lotery, J. Fingert   +11 more
semanticscholar   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source