Results 241 to 250 of about 325,097 (348)

Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities

Advanced Science, EarlyView.
The tongue's anterior epithelium is maintained by region‐specific stem/progenitor cells, yet in vitro models are limited. Long‐term expanding organoids are developed from adult mouse anterior tongue that retain region‐specific identity, cellular diversity, and gene regulatory features. These organoids differentiate into keratinocytes, Merkel‐like cells,
Seok‐Young Kim, Laurens H. G. Verweij, Lin Lin, Johan H. van Es, Jay Slack, Chris Winkel, Tito Candelli, Philip Lijnzaad, Thanasis Margaritis, Gerben E. Breimer, Karin Sanders, Marc van de Wetering, Hans Clevers   +12 more
wiley   +1 more source

Classification of polyphenol oxidases shows ancient gene duplication leading to two distinct enzyme types. [PDF]

iScience
Meitil IKS, de O G Silva C, Pedersen AG, Agger JW.   +3 more
europepmc   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Multiple Retrotransposon-mediated NF-YA Gene Duplication Events Recurred in Diverse Groups of Mammals at Different Ancestry Levels. [PDF]

Genome Biol Evol
Gallo A, Bernardini A, Polettini S, Dolfini D, Gnesutta N, Mantovani R.   +5 more
europepmc   +1 more source

Evidence for gene duplication forming similar binding folds for NAD(P)H and FAD in pyridine nucleotide‐dependent flavoenzymes

, 1991
James H. McKie, Kenneth T. Douglas
openalex   +1 more source

H2S Is a Potential Universal Reducing Agent for Prx6‐Type Peroxiredoxins

Advanced Science, EarlyView.
We report the identification of H2S as reducing agent for Prx6‐type peroxiredoxins. In contrast to common physiological reducing agents of other peroxiredoxins, HS− is small enough to access the active site of oxidized Prx6‐type enzymes in the fully‐folded protein conformation.
Lukas Lang, Laura Leiskau, Lea Bambach, Marcel Deponte   +3 more
wiley   +1 more source

<i>OTC</i> gene duplication as the possible cause of massive hyperammonaemia with a fatal prognosis. [PDF]

Mol Genet Metab Rep
Natalia B, Lukasz K, Dariusz R, Elzbieta S, Pawel K, Monika DZ, Pawel S, Elzbieta C, Mateusz B, Malgorzata R, Rafal P, Robert S.   +11 more
europepmc   +1 more source

The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP-related transcription factors

, 1992
R.S. Carter, N K Bhat, Aruna Basu, Narayan G. Avadhani   +3 more
openalex   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source