Results 61 to 70 of about 7,565,225 (388)

Maximum likelihood models and algorithms for gene tree evolution with duplications and losses

BMC Bioinformatics, 2011
Background The abundance of new genomic data provides the opportunity to map the location of gene duplication and loss events on a species phylogeny. The first methods for mapping gene duplications and losses were based on a parsimony criterion, finding ...
Burleigh Gordon J, Górecki Pawel, Eulenstein Oliver   +2 more
doaj   +1 more source

Duplicated genes evolve slower than singletons despite the initial rate increase

BMC Evolutionary Biology, 2004
Background Gene duplication is an important mechanism that can lead to the emergence of new functions during evolution. The impact of duplication on the mode of gene evolution has been the subject of several theoretical and empirical comparative-genomic ...
Koonin Eugene V, Wolf Yuri I, Jordan I King   +2 more
doaj   +1 more source

Overdosage of HNF1B Gene Associated With Annular Pancreas Detected in Neonate Patients With 17q12 Duplication

Frontiers in Genetics, 2021
The annular pancreas (AP) is a congenital anomaly of the pancreas that can cause acute abdominal pain and vomiting after birth. However, the genetic cause of AP is still unknown, and no study has reported AP in patients with 17q12 duplication. This study
Feifan Xiao, Feifan Xiao, Xiuyun Liu, Xiuyun Liu, Yulan Lu, Bingbing Wu, Renchao Liu, Bo Liu, Kai Yan, Huiyao Chen, Huiyao Chen, Guoqiang Cheng, Laishuan Wang, Qi Ni, Qi Ni, Gang Li, Ping Zhang, Xiaomin Peng, Yun Cao, Chun Shen, Huijun Wang, Wenhao Zhou, Wenhao Zhou, Wenhao Zhou   +23 more
doaj   +1 more source

A probabilistic model for gene content evolution with duplication, loss, and horizontal transfer

, 2005
We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gene loss, in addition to branch lengths in the phylogeny. The likelihood for
A.B. Simonson, B. Boussau, B. Snel, B. Snel, B.E. Dutilh, B.G. Mirkin, C. Pál, C.G. Kurland, D.H. Huson, E. Belda, E.A. Herniou, E.D. Green, E.J. Deeds, E.L.L. Sonnhammer, E.V. Koonin, F. Delsuc, F. Tekaia, G.D.P. Clarke, G.P. Karev, G.P. Karev, G.P. Karev, I.K. Jordan, J. Lin, J.A. Lake, J.O. Korbel, J.P. Gogarten, J.T. Herbeck, K.H. Wolfe, M. Csűrös, M. Pellegrini, M.G. Montague, M.W. Hahn, R.L. Tatusov, S. Karlin, S. Yang, S.T. Fitz-Gibbon, T. Pupko, V. Kunin, V. Kunin, W. Feller, W.J. Reed, X. Gu, Y. Boucher, Y.I. Wolf   +43 more
core   +2 more sources

Evolutionary ecology of opsin gene sequence, expression and repertoire. [PDF]

, 2017
Linking molecular evolution to biological function is a long-standing challenge in evolutionary biology. Some of the best examples of this involve opsins, the genes that encode the molecular basis of light reception.
Owens, Gregory L, Rennison, Diana J
core   +1 more source

The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates

Nature Communications, 2014
Vertebrate evolution has been shaped by several rounds of whole-genome duplications (WGDs) that are often suggested to be associated with adaptive radiations and evolutionary innovations. Due to an additional round of WGD, the rainbow trout genome offers
Camille Berthelot, Frédéric G Brunet, D. Chalopin, A. Juanchich, M. Bernard, Benjamin Noël, Pascal Bento, C. da Silva, Karine Labadie, A. Alberti, J. Aury, Alexandra Louis, P. Déhais, P. Bardou, J. Montfort, C. Klopp, Cédric Cabau, C. Gaspin, G. Thorgaard, M. Boussaha, E. Quillet, R. Guyomard, Delphine Galiana, Julien Bobe, J. Volff, C. Genet, P. Wincker, O. Jaillon, H. R. Crollius, Y. Guiguen   +29 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Gene Duplication to Reveal Adaptation Clue of Plant to Environmental Stress: a Case Study of NBS-LRR Genes in Soybean [PDF]

, 2016
Genes responsive to the environmental stresses which are retained after small scale duplication are part of plant genome duplication. However, information of duplicated genes that could be adaptive to environmental changes in plant is limited.
Asadi, N. (nFN), Lee, S. (Suk-Ha), Lestari, P. (Puji), Tasma, I. M. (I)   +3 more
core  

Duplication, concerted evolution and purifying selection drive the evolution of mosquito vitellogenin genes [PDF]

, 2010
Background Mosquito vitellogenin (Vtg) genes belong to a small multiple gene family that encodes the major yolk protein precursors required for egg production. Multiple Vtg genes have been cloned and characterized from several mosquito species, but their
Song Chen, Jennifer S Armistead, Katie N Provost-Javier, Joyce M Sakamoto, Jason L Rasgon   +4 more
core   +2 more sources