Results 81 to 90 of about 325,097 (348)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Phylogenomics of MADS-Box Genes in Plants — Two Opposing Life Styles in One Gene Family

Biology, 2013
The development of multicellular eukaryotes, according to their body plan, is often directed by members of multigene families that encode transcription factors.
Lydia Gramzow, Günter Theißen
doaj   +1 more source

Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans [PDF]

, 2014
We have used whole genome paired-end Illumina sequence data to identify tandem duplications in 20 isofemale lines of D. yakuba, and 20 isofemale lines of D. simulans and performed genome wide validation with PacBio long molecule sequencing. We identify 1,
Andolfatto, Peter, Cridland, Julie M., Hu, Tina T., Rogers, Rebekah L., Shao, Ling, Thornton, Kevin R.   +5 more
core   +3 more sources

Gene duplication and neofunctionalization: POLR3G and POLR3GL [PDF]

Genome Research, 2013
RNA polymerase III (Pol III) occurs in two versions, one containing the POLR3G subunit and the other the closely related POLR3GL subunit. It is not clear whether these two Pol III forms have the same function, in particular whether they recognize the same target genes.
Viviane Praz, Viviane Praz, Nouria Hernandez, Philippe Lhote, Laurence Florens, Michael P. Washburn, Michael P. Washburn, Marianne Renaud, Erwann Vieu   +8 more
openaire   +6 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

iGTP: A software package for large-scale gene tree parsimony analysis

BMC Bioinformatics, 2010
Background The ever-increasing wealth of genomic sequence information provides an unprecedented opportunity for large-scale phylogenetic analysis. However, species phylogeny inference is obfuscated by incongruence among gene trees due to evolutionary ...
Fernández-Baca David, Wehe André, Bansal Mukul S, Chaudhary Ruchi, Eulenstein Oliver   +4 more
doaj   +1 more source

Some asymptotic properties of duplication graphs

, 2003
Duplication graphs are graphs that grow by duplication of existing vertices, and are important models of biological networks, including protein-protein interaction networks and gene regulatory networks.
A.-L. Barabási, Alpan Raval, F. Chung, J. Kim, J.R. Banavar, R. Albert, R. Albert, R. Pastorras-Satorras, R.V. Solé, S.H. Storgatz   +9 more
core   +1 more source

Gene Duplication and Ectopic Gene Conversion in Drosophila [PDF]

Genes, 2011
The evolutionary impact of gene duplication events has been a theme of Drosophila genetics dating back to the Morgan School. While considerable attention has been placed on the genetic novelties that duplicates are capable of introducing, and the role that positive selection plays in their early stages of duplicate evolution, much less attention has ...
J. Roman Arguello, Tim Connallon
openaire   +3 more sources

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Interrogation of alternative splicing events in duplicated genes during evolution

BMC Genomics, 2011
Background Gene duplication provides resources for developing novel genes and new functions while retaining the original functions. In addition, alternative splicing could increase the complexity of expression at the transcriptome and proteome level ...
Chen Ting-Wen, Wu Timothy H, Ng Wailap V, Lin Wen-Chang   +3 more
doaj   +1 more source