Results 81 to 90 of about 6,833,475 (368)

Gene Duplication to Reveal Adaptation Clue of Plant to Environmental Stress: a Case Study of NBS-LRR Genes in Soybean [PDF]

, 2016
Genes responsive to the environmental stresses which are retained after small scale duplication are part of plant genome duplication. However, information of duplicated genes that could be adaptive to environmental changes in plant is limited.
Asadi, N. (nFN), Lee, S. (Suk-Ha), Lestari, P. (Puji), Tasma, I. M. (I)   +3 more
core  

Spider Transcriptomes Identify Ancient Large-Scale Gene Duplication Event Potentially Important in Silk Gland Evolution

Genome Biology and Evolution, 2015
The evolution of specialized tissues with novel functions, such as the silk synthesizing glands in spiders, is likely an influential driver of adaptive success.
Thomas H. Clarke, Jessica E. Garb, C. Hayashi, Peter Arensburger, Nadia A. Ayoub   +4 more
semanticscholar   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Modes of gene duplication contribute differently to genetic novelty and redundancy, but show parallels across divergent angiosperms. [PDF]

PLoS ONE, 2011
BACKGROUND: Both single gene and whole genome duplications (WGD) have recurred in angiosperm evolution. However, the evolutionary effects of different modes of gene duplication, especially regarding their contributions to genetic novelty or redundancy ...
Yupeng Wang, Xiyin Wang, Haibao Tang, Xu Tan, Stephen P Ficklin, F Alex Feltus, Andrew H Paterson   +6 more
doaj   +1 more source

Genome-scale phylogenetic analysis finds extensive gene transfer among Fungi [PDF]

, 2015
Although the role of lateral gene transfer is well recognized in the evolution of bacteria, it is generally assumed that it has had less influence among eukaryotes.
Boussau, Bastien, Daubin, Vincent, Davín, Adrián Arellano, Szöllősi, Gergely J., Tannier, Eric   +4 more
core   +4 more sources

The Evolutionary Fate of Alternatively Spliced Homologous Exons after Gene Duplication

Genome Biology and Evolution, 2015
Alternative splicing and gene duplication are the two main processes responsible for expanding protein functional diversity. Although gene duplication can generate new genes and alternative splicing can introduce variation through alternative gene ...
F. Abascal, M. Tress, A. Valencia
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The shape of human gene family phylogenies

BMC Evolutionary Biology, 2006
Background The shape of phylogenetic trees has been used to make inferences about the evolutionary process by comparing the shapes of actual phylogenies with those expected under simple models of the speciation process.
Cotton James A, Page Roderic DM
doaj   +1 more source

Importance of gene duplication in the evolution of genomic imprinting revealed by molecular evolutionary analysis of the type I MADS-box gene family in Arabidopsis species. [PDF]

PLoS ONE, 2013
The pattern of molecular evolution of imprinted genes is controversial and the entire picture is still to be unveiled. Recently, a relationship between the formation of imprinted genes and gene duplication was reported in genome-wide survey of imprinted ...
Takanori Yoshida, Akira Kawabe
doaj   +1 more source

Has gene duplication impacted the evolution of Eutherian longevity? [PDF]

, 2016
One of the greatest unresolved questions in aging biology is determining the genetic basis of interspecies longevity variation. Gene duplication is often the key to understanding the origin and evolution of important Eutherian phenotypes.
de Magalhaes, Joao Pedro, Doherty, Aoife
core   +1 more source