Results 101 to 110 of about 7,937 (203)
Tissue damage modeling in gene electrotransfer: The role of pH
Bioelectrochemistry, 2014 Optimal gene electrotransfer (GET) requires a compromise between maximum transgene expression and minimal tissue damage. GET in skeletal muscle can be improved by pretreatment with hyaluronidase which contributes to maximize transgene uptake and expression.
Olaiz N +7 more
openaire +5 more sources
Muscle &Nerve, Volume 72, Issue 1, Page 139-148, July 2025.ABSTRACT Introduction/Aims We previously demonstrated that leucine supplementation significantly reduces histone deacetylase 4 (HDAC4) expression induced by hindlimb immobilization, thereby attenuating the increase in HDAC4 protein levels and nuclear accumulation.
Paula K. N. Alves +6 more
wiley +1 more source
Dexamethasone Promotes Autophagy Dependent Ferroptosis of Placental Trophoblast Cells Through GRα
Journal of Cellular and Molecular Medicine, Volume 29, Issue 13, July 2025.ABSTRACT Dexamethasone (DEX) has been extensively employed for the treatment of pregnancy disorders related to preterm birth. However, the precise mechanism by which prenatal DEX exposure affects foetal development remains unclear. This study delves into investigating the influence of DEX and ferroptosis inhibitors on the activity and ferroptosis level
Junlei Lu +4 more
wiley +1 more source
Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii [PDF]
, 2010 We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field.
Cree, Michael J. +3 more
core +2 more sources
Current Protocols, Volume 5, Issue 6, June 2025.Abstract Plant autophagy is a catabolic process where cellular components such as protein aggregates and dysfunctional organelles are degraded and recycled to maintain homeostasis and facilitate stress resilience. Autophagy relies on a double‐membrane vesicle called the autophagosome, which delivers cellular cargo to the vacuole for degradation.
William Agbemafle +2 more
wiley +1 more source
Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells
Molecular Therapy: Nucleic Acids, 2016 In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene.
Katarina Znidar +3 more
doaj +1 more source
Synthesis of electroneutralized amphiphilic copolymers with peptide dendrons for intramuscular gene delivery [PDF]
, 2016 Intramuscular gene delivery materials are of great importance in plasmid-based gene therapy system, but there is limited information so far on how to design and synthesize them.
Chai, Qiuxia +7 more
core +1 more source
Defective Processing of Cytoplasmic and Chloroplast Ribosomal RNA in the Absence of Arabidopsis DXO1
Plant, Cell &Environment, Volume 48, Issue 6, Page 4227-4244, June 2025.ABSTRACT Decapping 5′‐3′ exoribonucleases from the DXO/Rai1 family are highly conserved among eukaryotes and exhibit diverse enzymatic activities depending on the organism. The biochemical and structural properties of the plant DXO1 differ from the yeast and animal counterparts, which is reflected in the in vivo functions of this enzyme.
Monika Zakrzewska‐Placzek +5 more
wiley +1 more source
The Quality of Ornamental Japanese Carp (Cyprinus Carpio Var. Koi) After Electroporation as a Gene Material Transfer Method [PDF]
, 2016 Spermatozoa are male gametes that have an advantage in acting as gene transfer media (SMGT), because in transferring genetic material, sperm uses relatively natural vectors.
Kilawati, Y. (Yuni) +2 more
core +2 more sources
The Evaluation of Mefloquine Drug Repurposing on Acute Myeloid Leukemia [PDF]
, 2018 The aim of this study is to observe cell proliferation, cell viability, apoptosis, and autophagy on acute myeloid leukemia (AML) cell lines, NB4 and U937, with the drug repurposing of mefloquine (MQ).
Corey, Seth +3 more
core +1 more source