Results 131 to 140 of about 6,790,032 (188)

Advanced electrotransfer for IL-12 gene immunotherapy in melanoma: Challenges and possibilities. [PDF]

Mol Ther Oncol
Niwa Y, Igarashi J.
europepmc   +1 more source

Application of nanostructured biochips for efficient cell transfection microarrays [PDF]

, 2007
Akkamsetty, Yamini, Hayes, Jason, Hook, Andrew Leslie, Thissen, Helmut Werner, Voelcker, Nicolas Hans   +4 more
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Gene Electrotransfer and DNA Sensing

Bioelectricity
L. Heller
semanticscholar   +2 more sources

Abstract CT115: Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: A phase I clinical trial

Cancer Research, 2023
Immunotherapies with monoclonal antibodies (checkpoint inhibitors) are currently being intensively researched and have led to excellent response in many cases in various tumors.
G. Serša, M. Čemažar, Črt Jamšek, P. Strojan, T. Jesenko, M. Bošnjak, Aleš Grošelj   +6 more
semanticscholar   +1 more source

Gene Electrotransfer Clinical Trials

2015
Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of approaches including lipid or polymer conjugation, particle-mediated delivery, hydrodynamic delivery, ultrasound or electroporation.
Richard, Heller, Loree C, Heller
openaire   +2 more sources

The Role of Electrophoresis in Gene Electrotransfer

The Journal of Membrane Biology, 2010
Gene electrotransfer is an established method for gene delivery which uses high-voltage pulses to increase the permeability of a cell membrane and enables transfer of genes. Poor plasmid mobility in tissues is one of the major barriers for the successful use of gene electrotransfer in gene therapy.
M, Pavlin, K, Flisar, M, Kanduser
openaire   +2 more sources

High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy.

Radiology, 2020
This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical oncology to treat solid tumors with irreversible electroporation (IRE) and electrochemotherapy (ECT).
B. Geboers, H. Scheffer, P. Graybill, A. Ruarus, Sanne Nieuwenhuizen, R. Puijk, P. M. van den Tol, R. Davalos, B. Rubinsky, T. D. de Gruijl, D. Miklavčič, M. Meijerink   +11 more
semanticscholar   +1 more source

Gene Electrotransfer to Tumor

2011
In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models.
Loree C. Heller, Richard Heller
openaire   +1 more source

Gene Electrotransfer to Skin

2011
Gene electrotransfer to skin is achieving increasing interest and is likely to gain considerable clinical application due to the ease with which it is performed and the safety of the procedure. There is a potential use of gene electrotransfer to skin in e.g., DNA vaccinations, local production of therapeutic molecules as well as production of molecules
Anita Gothelf, Julie Gehl
openaire   +1 more source

Interleukin-12 Gene Electrotransfer in Veterinary Oncology

2021
Interleukin-12 has been a promising candidate for cancer treatment for over 20 years. And from its infamous start, the gene electrotransfer delivery has regained assurance of the safe and effective use of interleukin-12 in cancer treatment. Here, basic facts about interleukin-12 are presented with a focus on its antitumor action and the benefit of ...
Ursa Lampreht Tratar, Natasa Tozon, Nina Milevoj, Gregor Sersa, Ana Nemec, Katja Ursic, Maja Cemazar   +6 more
openaire   +1 more source