Results 11 to 20 of about 1,715,800 (269)
Open Biology, 2021 Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in Xenopus egg extract, MTBP forms an elongated tetramer with Treslin containing two molecules of each protein.
Ilaria Volpi +3 more
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SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Nature Communications, 2018 The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu +11 more
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Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition
Frontiers in Molecular Biosciences, 2022 The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes.
Oleg Semenov +6 more
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Structural basis underlying viral hijacking of a histone chaperone complex
Nature Communications, 2016 The Epstein-Barr virus tegument protein BNRF1 is required for the establishment of selective viral gene expression during latency and interacts with the histone chaperone DAXX.
Hongda Huang +6 more
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Bio-Protocol, 2021 Polysome profile analysis is a popular method for separating polysomes and ribosomal subunits and is typically achieved using a sucrose density gradient (SDG).
Harunori Yoshikawa +4 more
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Scientific Reports, 2017 Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C.
Sarah-Lena Offenburger +4 more
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The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element
Genome Biology, 2017 Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar +12 more
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A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
Nature Communications, 2020 SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional ...
Elena Grossi +8 more
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BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research, 2023 Background Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood.
Juan Rodrigo Patiño-Mercau +8 more
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A role for p53 in telomere protection
Molecular & Cellular Oncology, 2017 Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
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