Results 41 to 50 of about 2,019,582 (297)

The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II

Cell Reports, 2018
Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear cell
Marco Trizzino, Elisa Barbieri, Ana Petracovici, Shuai Wu, Sarah A. Welsh, Tori A. Owens, Silvia Licciulli, Rugang Zhang, Alessandro Gardini   +8 more
doaj   +1 more source

Galectin genes: Regulation of expression

Glycoconjugate Journal, 2002
In this review we have summarized the more recent studies on the expression of mammalian galectins. One interesting observation that can be made is that in most of microarrays and/or differential display analysis performed in recent years one or more galectins have been picked up.
CHIARIOTTI, LORENZO, SALVATORE, PAOLA, FRUNZIO, RODOLFO, BRUNI, CARMELO BRUNO   +3 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Wigwams : identifying gene modules co-regulated across multiple biological conditions [PDF]

, 2014
Motivation: Identification of modules of co-regulated genes is a crucial first step towards dissecting the regulatory circuitry underlying biological processes. Co-regulated genes are likely to reveal themselves by showing tight co-expression, e.g.
Rhodes, Johanna, Jenkins, Dafyd J, Jironkin, Aleksey, Kiddle, Steven J., Beynon, Jim, Buchanan-Wollaston, Vicky, Kiddle, Steven J, Hills, Claire E., Denby, Katherine J, Denby, Katherine J., Hill, Claire, Jenkins, Dafyd J., Zhang, Peijun, Polański, Krzysztof, Kiddle, Steven, Ott, Sascha, Rhodes, Johanna; id_orcid   +16 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model

Nature Communications, 2019
Progressive familial intrahepatic cholestasis type 3 is a disease caused by mutations in the gene encoding the multidrug resistance protein 3, and has limited treatment options.
Nicholas D. Weber, Leticia Odriozola, Javier Martínez-García, Veronica Ferrer, Anne Douar, Bernard Bénichou, Gloria González-Aseguinolaza, Cristian Smerdou   +7 more
doaj   +1 more source

Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice

BMC Genomics, 2018
Background Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood.
Nikita I. Ershov, Natalya P. Bondar, Arina A. Lepeshko, Vasiliy V. Reshetnikov, Julia A. Ryabushkina, Tatiana I. Merkulova   +5 more
doaj   +1 more source

A mouse model for functional dissection of TAB1 O-GlcNAcylation [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: O-GlcNAcylation is a posttranslational modification associated with various physiological and pathophysiological processes including diabetes, cancer, neurodegeneration and inflammation.
Florence Authier, Villő Muha, Daan M.F. van Aalten   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Balancing noise and plasticity in gene expression [PDF]

, 2011
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Juan F. Poyatos, Djordje Bajic
core