Results 21 to 30 of about 1,893,955 (220)
A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
Nature Communications, 2020 SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional ...
Elena Grossi +8 more
doaj +1 more source
BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research, 2023 Background Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood.
Juan Rodrigo Patiño-Mercau +8 more
doaj +1 more source
Nongenomic regulation of gene expression
Current Opinion in Pediatrics, 2016 Purpose of review The purpose of this review is to highlight the recent advances in epigenetic regulation and chromatin biology for a better understanding of gene regulation related to human disease. Recent findings Alterations to chromatin influence genomic function, including gene
Iglesias-Platas I, Monk D
openaire +3 more sources
Wigwams : identifying gene modules co-regulated across multiple biological conditions [PDF]
, 2014 Motivation: Identification of modules of co-regulated genes is a crucial first step towards dissecting the regulatory circuitry underlying biological processes. Co-regulated genes are likely to reveal themselves by showing tight co-expression, e.g.
Rhodes, Johanna +16 more
core +1 more source
A role for p53 in telomere protection
Molecular & Cellular Oncology, 2017 Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress.
Stephen Tutton, Paul M. Lieberman
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Cell Reports, 2016 Epithelial-to-mesenchymal transition (EMT) confers several traits to cancer cells that are required for malignant progression. Here, we report that miR-27b-3p-mediated silencing of the single-strand RNA binding protein KHSRP is required for transforming ...
Margherita Puppo +8 more
doaj +1 more source
ISR8/IRF1-AS1 Is Relevant for IFNα and NF-κB Responses
Frontiers in Immunology, 2022 The study of the interferon (IFN) α-induced cell transcriptome has shown altered expression of several long non-coding RNAs (lncRNAs). ISR8/IRF1-AS1 (IFN stimulated RNA 8), located close to IFN regulatory factor 1 (IRF1) coding gene, transcribes a lncRNA
Marina Barriocanal +8 more
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Stochastic neural network models for gene regulatory networks [PDF]
, 2003 Recent advances in gene-expression profiling technologies provide large amounts of gene expression data. This raises the possibility for a functional understanding of genome dynamics by means of mathematical modelling.
Burrage K. +3 more
core +1 more source
ARID1A promotes genomic stability through protecting telomere cohesion
Nature Communications, 2019 Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in
Bo Zhao +16 more
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Cells, 2023 Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of nerve
Eugene N. Kozlov +9 more
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