Results 31 to 40 of about 1,893,955 (220)
Clinical & Translational Immunology, 2022 Objective Pre‐existing neutralising antibodies (NAbs) to adeno‐associated viruses (AAVs) remain an impediment for systemically administered AAV‐mediated gene therapy treatment in many patients, and various strategies are under investigation to overcome ...
Irene Ros‐Gañán +11 more
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Investigation of the Basic Steps in the Chromosome Conformation Capture Procedure
Frontiers in Genetics, 2021 A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence.
Oleg V. Bylino +5 more
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Neurotrophin Regulation of Gene Expression [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1997 ABSTRACT: The neurotrophins comprise a family of secreted proteins that elicit profound responses in cells of the developing and mature vertebrate nervous system including the regulation of neuronal survival and differentiation. The molecular mechanisms by which the neurotrophins exert their effects have been the subject of intense investigation ...
A, Bonni, M E, Greenberg
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Diurnal regulation of the brassinosteroid-biosynthetic CPD gene in Arabidopsis [PDF]
, 2006 Plant steroid hormones, brassinosteroids (BRs), are essential for normal photomorphogenesis. However, the mechanism by which light controls physiological functions via BRs is not well understood.
Bancos, Simona +8 more
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Regulation of gene expression by micrornas : targeting specificity, kinetics and function [PDF]
, 2011 Summary: Understanding gene regulation is a central question of molecular biology. For decades, gene expression was thought to be controlled by a complex network of proteins called transcription factors.
Hausser, Jean Albert René
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CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
Nature Communications, 2018 CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor ...
Sergey Karakashev +14 more
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The Tumor Suppressor ARID1A Controls Global Transcription via Pausing of RNA Polymerase II
Cell Reports, 2018 Summary: AT-rich interactive domain-containing proteins 1A and 1B (ARID1A and ARID1B) are mutually exclusive subunits of the chromatin remodeler SWI/SNF. ARID1A is the most frequently mutated chromatin regulator across all cancers, and ovarian clear cell
Marco Trizzino +8 more
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Regulation of Arabidopsis 14-3-3 gene expression by GABA. [PDF]
, 2006 The function in plants of the non-protein amino acid, gamma-aminobutyric acid (GABA) is poorly understood. In this study, we show that GABA down-regulates the expression of a large sub-set of 14-3-3 gene family members in Arabidopsis thaliana seedlings ...
Lancien, Muriel +3 more
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A mouse model for functional dissection of TAB1 O-GlcNAcylation [version 2; peer review: 2 approved]
Wellcome Open Research, 2020 Background: O-GlcNAcylation is a posttranslational modification associated with various physiological and pathophysiological processes including diabetes, cancer, neurodegeneration and inflammation.
Florence Authier +2 more
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Pharmacological regulation of gene expression [PDF]
Pharmacological Research, 2011 Pharmacological regulation of gene expression was one of the top professional interests of Dr. Costa. He promoted the idea that drugs can improve the endogenous mechanisms of synaptic plasticity by modulating gene expression. In this article I reflect upon Dr.
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