Results 61 to 70 of about 1,893,955 (220)

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

eLife, 2017
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule.
Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond   +8 more
doaj   +1 more source

Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53 [PDF]

, 2010
Background: The availability of various "omics" datasets creates a prospect of performing the study of genome-wide genetic regulatory networks. However, one of the major challenges of using mathematical models to infer genetic regulation from microarray ...
Junbai Wang, Tian, Tianhai, Tianhai Tian, Tian, T., Wang, Junbai, Tian Tianhai, Wang Junbai, Wang, J.   +7 more
core   +1 more source

NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands

Redox Biology, 2020
Saliva plays an essential role in the maintenance of oral health. The oral cavity environment changes during aging mainly due to alterations in the secretion and composition of saliva.
Sisca Meida Wati, Daisuke Matsumaru, Hozumi Motohashi   +2 more
doaj   +1 more source

Intestinal gene expression in pigs: effects of reduced feed intake during weaning and potential impact of dietary components

, 2011
The weaning transition is characterised by morphological, histological and microbial changes, often leading to weaning-associated disorders. These intestinal changes can partly be ascribed to the lack of luminal nutrition arising from the reduced feed ...
Bauer, E., Verstegen, M.W.A., Metzler-Zebeli, B.U., Mosenthin, R.   +3 more
core   +1 more source

Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss

npj Aging and Mechanisms of Disease, 2020
Age-related hearing loss (AHL) is a progressive sensorineural hearing loss in elderly people. Although no prevention or treatments have been established for AHL, recent studies have demonstrated that oxidative stress is closely related to pathogenesis of
Tetsuya Oishi, Daisuke Matsumaru, Nao Ota, Hiroshi Kitamura, Tianxiang Zhang, Yohei Honkura, Yukio Katori, Hozumi Motohashi   +7 more
doaj   +1 more source

Regulation of virulence gene expression [PDF]

Virulence, 2014
The bacterial pathogen that finds itself, either by accident or design, within the human or animal host, senses and adapts to the prevailing conditions by modulating its gene expression on a global...
Thomas, M.S., Wigneshweraraj, S.
openaire   +3 more sources

An extended Kalman filtering approach to modeling nonlinear dynamic gene regulatory networks via short gene expression time series

, 2009
Copyright [2009] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services.
Liu, Y, Liu, X, Wang, Z, Liang, Y, Vinciotti, V   +4 more
core   +1 more source

The use of general and specific combining abilities in a context of gene expression relevant to plant breeding

, 2008
Many common traits are believed to be a composite reflection of multiple genetic and environmental factors. Recent advances suggest that subtle variations in the regulation of gene expression may contribute to quantitative traits.
Vuylsteke, M., Eeuwijk, F.A., van
core   +1 more source

Nuclear Photosynthetic Gene Expression Is Synergistically Modulated by Rates of Protein Synthesis in Chloroplasts and Mitochondria [PDF]

, 2006
Arabidopsis thaliana mutants prors1-1 and -2 were identified on the basis of a decrease in effective photosystem II quantum yield. Mutations were localized to the 5'-untranslated region of the nuclear gene PROLYL-tRNA SYNTHETASE1 (PRORS1), which acts in ...
Leister, Dario, Masiero, Simona, H. P. Braun, Pesaresi, Paolo, Braun, Hans-Peter, E. Glaser, D. Leister, Glaser, Elzbieta, Bhushan, Shashi, F. Salamini, H. Eubel, Eubel, Holger, S. Bhushan, Salamini, Francesco, P. Pesaresi, S. Masiero   +15 more
core   +1 more source

TcZC3HTTP, a regulatory element that contributes to Trypanosoma cruzi cell proliferation

Microbiology Spectrum
Post-transcriptional regulation of gene expression is a critical process for adapting to and surviving Trypanosoma cruzi, a parasite with a complex life cycle.
Bruno Accioly Alves Romagnoli, Aline Castro Rodrigues Lucena, Eden Ribeiro Freire, Isadora Filipaki Munhoz da Rocha, Lysangela Ronalte. Alves, Samuel Goldenberg   +5 more
doaj   +1 more source