Results 11 to 20 of about 3,483,446 (299)

Multivariate Surprisal Analysis of Gene Expression Levels [PDF]

Entropy, 2016
We consider here multivariate data which we understand as the problem where each data point i is measured for two or more distinct variables. In a typical situation there are many data points i while the range of the different variables is more limited ...
Francoise Remacle, Andrew S. Goldstein, Raphael D. Levine   +2 more
doaj   +2 more sources

Precise tuning of gene expression levels in mammalian cells [PDF]

Nature Communications, 2019
Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely
Yale S. Michaels, Mike B. Barnkob, Hector Barbosa, Toni A. Baeumler, Mary K. Thompson, Violaine Andre, Huw Colin-York, Marco Fritzsche, Uzi Gileadi, Hilary M. Sheppard, David J. H. F. Knapp, Thomas A. Milne, Vincenzo Cerundolo, Tudor A. Fulga   +13 more
doaj   +4 more sources

Blood gene expression signatures predict exposure levels [PDF]

Proceedings of the National Academy of Sciences, 2007
To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP) intoxication, the leading cause of liver failure in the U.S.
P R, Bushel, A N, Heinloth, J, Li, L, Huang, J W, Chou, G A, Boorman, D E, Malarkey, C D, Houle, S M, Ward, R E, Wilson, R D, Fannin, M W, Russo, P B, Watkins, R W, Tennant, R S, Paules   +14 more
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A gene-level test for directional selection on gene expression

GENETICS, 2022
Abstract Most variants identified in human genome-wide association studies and scans for selection are noncoding. Interpretation of their effects and the way in which they contribute to phenotypic variation and adaptation in human populations is therefore limited by our understanding of gene regulation and the difficulty of ...
Laura L. Colbran, Fabian C. Ramos-Almodovar, Iain Mathieson   +2 more
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DNA replication timing influences gene expression level [PDF]

Journal of Cell Biology, 2017
Eukaryotic genomes are replicated in a reproducible temporal order; however, the physiological significance is poorly understood. We compared replication timing in divergent yeast species and identified genomic features with conserved replication times. Histone genes were among the earliest replicating loci in all species.
Carolin A. Müller, Conrad A. Nieduszynski   +1 more
openaire   +3 more sources

Histone modification levels are predictive for gene expression [PDF]

Proceedings of the National Academy of Sciences, 2010
Histones are frequently decorated with covalent modifications. These histone modifications are thought to be involved in various chromatin-dependent processes including transcription. To elucidate the relationship between histone modifications and transcription, we derived quantitative models to predict the expression level of genes from histone ...
Karlic, R., Chung, H., Lasserre, J., Vlahovicek, K., Vingron, M.   +4 more
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Isoform level expression profiles provide better cancer signatures than gene level expression profiles [PDF]

Genome Medicine, 2013
Abstract Background The majority of mammalian genes generate multiple transcript variants and protein isoforms through alternative transcription and/or alternative splicing, and the dynamic changes at the transcript/isoform level between non-oncogenic and cancer cells remain largely unexplored.
Zhang, ZhongFa, Pal, Sharmistha, Bi, Yingtao, Tchou, Julia, Davuluri, Ramana V   +4 more
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Expressive genomic hybridisation: gene expression profiling at the cytogenetic level [PDF]

Molecular Pathology, 2003
To describe a cytogenetic technique suitable for the rapid assessment of global gene expression that is based on comparative genomic hybridisation (CGH), and to use it to understand the relation between genetic amplifications and gene expression.Whereas traditional CGH uses DNA as test and reference in hybridisations, expressive genomic hybridisation ...
F, Al-Mulla, M, Al-Maghrebi, G, Varadharaj   +2 more
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Gene expression levels in lymphoma [PDF]

Blood, 2007
[Comment on Sakhinia et al, page 3922][1]In the United States, 59 000 people were diagnosed with non-Hodgkin lymphoma during 2006, and 19 000 died of the disease. Translational molecular research is a high priority; however, routine measurement of predictive gene expression levels has ...
openaire   +1 more source

Gene location affects expression level in Salmonella typhimurium [PDF]

Journal of Bacteriology, 1987
Directed translocation of an expressed gene (hisD) provided strains to test for position effects on gene expression in Salmonella typhimurium. The predominant position effect seems to be caused by the gene dosage of a chromosomal site; the orientation of the translocated genes did not affect expression, and no deviant positions were found.
M B, Schmid, J R, Roth
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