Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum. [PDF]
PLoS Pathogens, 2009 Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease.
Jose C Garcia-Garcia +3 more
doaj +1 more source
The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7 [PDF]
, 2014 Classical studies have focused on the role that individual regulators play in controlling virulence gene expression. An emerging theme, however, is that bacterial metabolism also plays a key role in this process.
Abernathy +59 more
core +2 more sources
The BvgAS Regulon of
mBio, 2017 Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA.
Kyung Moon +6 more
doaj +1 more source
Microorganisms, 2022 Prokaryotic transcription was extensively studied over the last half-century. A great deal of data has been accumulated regarding the control of gene expression by transcription factors regulating their target genes by binding at specific DNA sites ...
Diana Le Berre +3 more
doaj +1 more source
Characterisation of the effects of salicylidene acylhydrazide compounds on type three secretion in Escherichia coli O157:H7 [PDF]
, 2009 Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of <i>Escherichia ...
Elofsson, M. +9 more
core +3 more sources
Genome wide expression profiling reveals suppression of host defence responses during colonisation by Neisseria meningitides but not N. lactamica. [PDF]
, 2011 Both Neisseria meningitidis and the closely related bacterium Neisseria lactamica colonise human nasopharyngeal mucosal surface, but only N. meningitidis invades the bloodstream to cause potentially life-threatening meningitis and septicaemia.
Hibberd, Martin L +4 more
core +1 more source
BMC Microbiology, 2017 Background Bacillus pumilus can secret abundant extracellular enzymes, and may be used as a potential host for the industrial production of enzymes. It is necessary to understand the metabolic processes during cellular growth.
Lin-Li Han +8 more
doaj +1 more source
Interaction of two photoreceptors in the regulation of bacterial photosynthesis genes [PDF]
, 2012 The expression of photosynthesis genes in the facultatively photosynthetic bacterium Rhodobacter sphaeroides is controlled by the oxygen tension and by light quantity. Two photoreceptor proteins, AppA and CryB, have been identified in the past, which are
Frühwirth, Sebastian +5 more
core +1 more source
mBio, 2017 In enteropathogenic Escherichia coli (EPEC), the locus of enterocyte effacement (LEE) encodes a type 3 secretion system (T3SS) essential for pathogenesis.
Hervé Leh +5 more
doaj +1 more source
Dynamics of immune system gene expression upon bacterial challenge and wounding in a social insect (Bombus terrestris). [PDF]
PLoS ONE, 2011 The innate immune system which helps individuals to combat pathogens comprises a set of genes representing four immune system pathways (Toll, Imd, JNK and JAK/STAT). There is a lack of immune genes in social insects (e.g.
Silvio Erler +2 more
doaj +1 more source