Results 31 to 40 of about 7,377,787 (300)

Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems

Frontiers in Cellular and Infection Microbiology, 2014
Toxin-antitoxin (TA) systems are small genetic elements ubiquitous in prokaryotic genomes that encode toxic proteins targeting various vital cellular functions.
Ralph eBertram, Christopher F Schuster
doaj   +1 more source

A highly conserved sRNA downregulates multiple genes, including a σ54 transcriptional activator, in the virulence mode of Bordetella pertussis

mBio
Bacterial small non-coding RNA (sRNAs), together with the RNA chaperone Hfq, post-transcriptionally regulate gene expression by affecting ribosome binding or mRNA stability.
Minji Sim, Jeffers Nguyen, Karolína Škopová, Kyungyoon Yoo, Chin-Hsien Tai, Leslie Knipling, Qing Chen, David Kim, Summer Nolan, Rawan Elaksher, Nadim Majdalani, Hernan Lorenzi, Scott Stibitz, Kyung Moon, Deborah M. Hinton   +14 more
doaj   +1 more source

Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells [PDF]

ACS Synthetic Biology, 2018
Functional genomics studies in minimal mycoplasma cells enable unobstructed access to some of the most fundamental processes in biology. Conventional transposon bombardment and gene knockout approaches often fail to reveal functions of genes that are essential for viability, where lethality precludes phenotypic characterization.
Ana M. Mariscal, Shigeyuki Kakizawa, Jonathan Y. Hsu, Kazuki Tanaka, Luis González-González, Alicia Broto, Enrique Querol, Maria Lluch-Senar, Carlos Piñero-Lambea, Lijie Sun, Philip D. Weyman, Kim S. Wise, Chuck Merryman, Gavin Tse, Adam J. Moore, Clyde A. Hutchison, Hamilton O. Smith, Masaru Tomita, J. Craig Venter, John I. Glass, Jaume Piñol, Yo Suzuki   +21 more
openaire   +4 more sources

Roles of DNA Adenine Methylation in Regulating Bacterial Gene Expression and Virulence [PDF]

Infection and Immunity, 2001
DNA methylation provides a mechanism by which additional information is imparted to DNA, and such epigenetic information can alter the timing and targeting of cellular events ([47][1]). DNA methylation occurs throughout the living world, including bacteria, plants, and mammals. Until recently,
D A, Low, N J, Weyand, M J, Mahan
openaire   +2 more sources

Orthologous transcription factors in bacteria have different functions and regulate different genes. [PDF]

PLoS Computational Biology, 2007
Transcription factors (TFs) form large paralogous gene families and have complex evolutionary histories. Here, we ask whether putative orthologs of TFs, from bidirectional best BLAST hits (BBHs), are evolutionary orthologs with conserved functions.
Morgan N Price, Paramvir S Dehal, Adam P Arkin   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulation of bacterial virulence gene expression by cell envelope stress responses [PDF]

Virulence, 2014
The bacterial cytoplasm lies within a multilayered envelope that must be protected from internal and external hazards. This protection is provided by cell envelope stress responses (ESRs), which detect threats and reprogram gene expression to ensure survival.
Josué, Flores-Kim, Andrew J, Darwin
openaire   +2 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Control of Bacterial Sulfite Detoxification by Conserved and Species-Specific Regulatory Circuits

Frontiers in Microbiology, 2019
Although sulfite, a by-product of the degradation of many sulfur compounds, is highly reactive and can cause damage to DNA, proteins and lipids, comparatively little is known about the regulation of sulfite-oxidizing enzyme (SOEs) expression.
Yi Jie Chelsea Tan, Chengzhi Zhao, Marufa Nasreen, Leo O’Rourke, Rabeb Dhouib, Leah Roberts, Ying Wan, Scott A. Beatson, Ulrike Kappler   +8 more
doaj   +1 more source

Do small RNAs unlock the below ground microbiome-plant interaction mystery?

Frontiers in Molecular Biosciences, 2022
Over the past few decades, regulatory RNAs, such as small RNAs (sRNAs), have received increasing attention in the context of host-microbe interactions due to their diverse roles in controlling various biological processes in eukaryotes.
Roshan Regmi, Roshan Regmi, C. Ryan Penton, C. Ryan Penton, C. Ryan Penton, Jonathan Anderson, Jonathan Anderson, Vadakattu V. S. R. Gupta, Vadakattu V. S. R. Gupta   +8 more
doaj   +1 more source