Results 51 to 60 of about 7,377,787 (300)

Mechanism of Gene Regulation by a Staphylococcus aureus Toxin

mBio, 2016
The virulence of many bacterial pathogens, including the important human pathogen Staphylococcus aureus, depends on the secretion of frequently large amounts of toxins. Toxin production involves the need for the bacteria to make physiological adjustments
Hwang-Soo Joo, Som S. Chatterjee, Amer E. Villaruz, Seth W. Dickey, Vee Y. Tan, Yan Chen, Daniel E. Sturdevant, Stacy M. Ricklefs, Michael Otto   +8 more
doaj   +1 more source

Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions

mBio, 2022
Despite being in a golden age of bacterial epigenomics, little work has systematically examined the plasticity and functional impacts of the bacterial DNA methylome.
Jeffrey S. Bourgeois, Caroline E. Anderson, Liuyang Wang, Jennifer L. Modliszewski, Wei Chen, Benjamin H. Schott, Nicolas Devos, Dennis C. Ko   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Divergent roles of CprK paralogues from Desulfitobacterium hafniense in activating gene expression [PDF]

, 2008
Gene duplication and horizontal gene transfer play an important role in the evolution of prokaryotic genomes. We have investigated the role of three CprK paralogues from the cAMP receptor protein-fumarate and nitrate reduction regulator (CRP-FNR) family ...
Vos, W.M., de, Smidt, H., Gabor, K., Sene, K.H., Oost, J., van der   +4 more
core   +1 more source

Bacterial riboswitches and RNA thermometers: Nature and contributions to pathogenesis

Non-coding RNA Research, 2018
Bacterial pathogens are always challenged by fluctuations of chemical and physical parameters that pose serious threats to cellular integrity and metabolic status.
Jameel M. Abduljalil
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Genome-wide analysis of growth phase-dependent translational and transcriptional regulation in halophilic archaea : research article [PDF]

, 2007
Background Differential expression of genes can be regulated on many different levels. Most global studies of gene regulation concentrate on transcript level regulation, and very few global analyses of differential translational efficiencies exist.
Schuster Stephan C, Lange, Christian, Oesterhelt, Dieter, Raddatz, Günter, Dieter Oesterhelt, Soppa, Jörg (Prof. Dr.), Jens Twellmeyer, Christian Lange, Soppa Jörg, Twellmeyer, Jens, Zaigler, Alexander, Oesterhelt Dieter, Jörg Soppa, Günter Raddatz, Lange, C., Raddatz Günter, Zaigler Alexander, Soppa, J., Lange Christian, Schuster, S., Zaigler, A., Schuster, Stephan C., Alexander Zaigler, Oesterhelt, D., Hammelmann Mathias, Raddatz, G., Stephan C Schuster, Mathias Hammelmann, Hammelmann, Mathias, Twellmeyer Jens, Hammelmann, M., Twellmeyer, J.   +31 more
core   +1 more source

Expression profiles of XIK1 and OsSWEET14 genes in parental and back‐ crossing rice lines after Xanthomonas oryzae pv. oryzae infection

Indonesian Journal of Biotechnology
Oryza sativa L. ssp. indica (RD47 cultivar) is a major commercial rice variety known for its highly stable yields. However, it is highly susceptible to bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo).
Atirada Boondech, Kawee Sujipuli, Kumrop Ratanasut, Tepsuda Rungrat, Thanita Boonsangsrom, Niran Aeksiri, Wittaya Tawong, Pongsanat Pongcharoen   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Role of Bacteriophage-Derived Small RNA Molecules in Bacterial and Phage Interactions

Viruses
Small regulatory RNAs (sRNAs) play a critical role in bacterial gene expression, modulating various cellular processes, including stress responses, metabolism, virulence, and many others.
Natalia Lewandowska, Sylwia Bloch, Aleksandra Łukasiak, Wojciech Wesołowski, Grzegorz Węgrzyn, Bożena Nejman-Faleńczyk   +5 more
doaj   +1 more source