Results 71 to 80 of about 7,377,787 (300)

Balancing noise and plasticity in gene expression [PDF]

, 2011
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Juan F. Poyatos, Djordje Bajic
core  

Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness

Scientific Reports, 2017
Lower respiratory tract infection (LRTI) commonly causes hospitalization in adults. Because bacterial diagnostic tests are not accurate, antibiotics are frequently prescribed. Peripheral blood gene expression to identify subjects with bacterial infection
Soumyaroop Bhattacharya, Alex F. Rosenberg, Derick R. Peterson, Katherine Grzesik, Andrea M. Baran, John M. Ashton, Steven R. Gill, Anthony M. Corbett, Jeanne Holden-Wiltse, David J. Topham, Edward E. Walsh, Thomas J. Mariani, Ann R. Falsey   +12 more
doaj   +1 more source

Transcriptional regulation of bacterial virulence gene expression by molecular oxygen and nitric oxide [PDF]

Virulence, 2014
Molecular oxygen (O2) and nitric oxide (NO) are diatomic gases that play major roles in infection. The host innate immune system generates reactive oxygen species and NO as bacteriocidal agents and both require O2 for their production. Furthermore, the ability to adapt to changes in O2 availability is crucial for many bacterial pathogens, as many ...
Green, J., Rolfe, M.D., Smith, L.J.
openaire   +3 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Transcriptional regulation of the human c-myc gene [PDF]

, 1988
The involvement of c-myc in the genesis of animal neoplasia is now well documented for several systems. In order to define the precise role played by the myc gene in tumorigenesis, a better understanding of the normal regulation of myc expression is ...
Wilkie, N M, Whitelaw, B, Lang, J C, Talbot, S   +3 more
core  

Modulating bacterial nanocellulose crystallinity through post-transcriptional repression in Komagataeibacter xylinus

Carbohydrate Polymer Technologies and Applications
Bacterial nanocellulose (BC) is a versatile biomaterial, with its microstructural features fundamentally influencing its properties and functionality across various applications.
Rahul Mangayil, Essi Sarlin, Tom Ellis, Ville Santala   +3 more
doaj   +1 more source

The Stringent Response Promotes Antibiotic Resistance Dissemination by Regulating Integron Integrase Expression in Biofilms

mBio, 2016
Class 1 integrons are genetic systems that enable bacteria to capture and express gene cassettes. These integrons, when isolated in clinical contexts, most often carry antibiotic resistance gene cassettes.
Emilie Strugeon, Valentin Tilloy, Marie-Cécile Ploy, Sandra Da Re   +3 more
doaj   +1 more source

TetR Regulated in vivo Repression Technology to Identify Conditional Gene Silencing in Genetically Engineerable Bacteria Using Vibrio cholerae Murine Infections as Model System

Bio-Protocol, 2020
Investigation of bacterial gene regulation upon environmental changes is still a challenging task. For example, Vibrio cholerae, a pathogen of the human gastrointestinal tract, faces diverse transient conditions in different compartments upon oral ...
Franz Zingl, Fabian Mitterer, Himadri Thapa, Stefan Schild   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Broad-Host-Range Shuttle Vectors for Screening of Regulated Promoter Activity in Viridans Group Streptococci: Isolation of a pH-Regulated Promoter [PDF]

, 2000
Viridans group streptococci are major constituents of the normal human oral flora and are also identified as the predominant pathogenic bacteria in native valve infective endocarditis.
Zaat, S. A., Kok, Jan, Zaat, SAJ, Kok, J, Dankert, J., Vriesema, A. J., Vriesema, Aldwin J.M.,, Sebastian A. J. Zaat, Brinkman, R., Jan Kok, Jacob Dankert, Zaat, Sebastian A.J.,, Rene ́ Brinkman, Brinkman, René,, Kok, Jan,, Vriesema, AJM, Dankert, Jacob,, Brinkman, René, Vriesema, Aldwin J.M., Aldwin J. M. Vriesema, Zaat, Sebastian A.J.   +20 more
core   +2 more sources