Results 41 to 50 of about 99,227 (260)

Using the cre-lox recombination system to assess functional impairment caused by amino acid substitutions in yeast proteins

Biological Procedures Online, 2004
A method was developed to assess the functional significance of a sequence motif in yeast Upf3p, a protein required for nonsense-mediated mRNA decay (NMD).
Shirley Renee L., Richards M. Rachel, Culbertson Michael R.   +2 more
doaj   +1 more source

FgHtf1 Regulates Global Gene Expression towards Aerial Mycelium and Conidiophore Formation in the Cereal Fungal Pathogen Fusarium graminearum

Applied and Environmental Microbiology, 2020
The homeobox gene family of transcription factors is known to be involved in the development and conidiation of filamentous fungi. However, the regulatory mechanisms and downstream targets of homeobox genes remain unclear. FgHtf1 is a homeobox transcription factor that is required for phialide development and conidiogenesis in the plant ...
Gaili Fan, Huawei Zheng, Kai Zhang, Veena Devi Ganeshan, Stephen Obol Opiyo, Dan Liu, Mingyang Li, Guangpu Li, Thomas K. Mitchell, Yingzi Yun, Zonghua Wang, Guo-dong Lu   +11 more
openaire   +3 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

eLife
The epigenetic reader SntB was identified as an important transcriptional regulator of growth, development, and secondary metabolite synthesis in Aspergillus flavus. However, the underlying molecular mechanism is still unclear.
Dandan Wu, Chi Yang, Yanfang Yao, Dongmei Ma, Hong Lin, Ling Hao, Wenwen Xin, Kangfu Ye, Minghui Sun, Yule Hu, Yanling Yang, Zhenhong Zhuang   +11 more
doaj   +1 more source

Comparative Transcriptome Analyses in Zymoseptoria tritici Reveal Significant Differences in Gene Expression Among Strains During Plant Infection

Molecular Plant-Microbe Interactions, 2017
Zymoseptoria tritici is an ascomycete fungus that causes Septoria tritici blotch, a globally distributed foliar disease on wheat. Z. tritici populations are highly polymorphic and exhibit significant quantitative variation for virulence.
Javier Palma-Guerrero, Xin Ma, Stefano F. F. Torriani, Marcello Zala, Carolina S. Francisco, Fanny E. Hartmann, Daniel Croll, Bruce A. McDonald   +7 more
doaj   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Large-Scale Comparative Analysis of Eugenol-Induced/Repressed Genes Expression in Aspergillus flavus Using RNA-seq

Frontiers in Microbiology, 2018
Aflatoxin B1 (AFB1), which is mainly produced by Aspergillus flavus and Aspergillus parasiticus, is the most toxic and hepatocarcinogenic polyketide known.
Cong Lv, Ping Wang, Longxue Ma, Mumin Zheng, Yang Liu, Fuguo Xing   +5 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Quantitative Characterization of Gene Regulatory Circuits Associated With Fungal Secondary Metabolism to Discover Novel Natural Products

Advanced Science
Microbial genetic circuits are vital for regulating gene expression and synthesizing bioactive compounds. However, assessing their strength and timing, especially in multicellular fungi, remains challenging.
Xinran Xu, Yanhong Sun, Anxin Zhang, Sijia Li, Shu Zhang, Sijing Chen, Chunbo Lou, Lei Cai, Yihua Chen, Chunxiong Luo, Wen‐Bing Yin   +10 more
doaj   +1 more source

Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development

BMC Genomics, 2012
Background During sexual development, filamentous ascomycetes form complex, three-dimensional fruiting bodies for the protection and dispersal of sexual spores.
Teichert Ines, Wolff Gabriele, Kück Ulrich, Nowrousian Minou   +3 more
doaj   +1 more source