Results 161 to 170 of about 638,559 (231)

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Schwann Cell Expression Pattern in Human Melanomas: In Silico and Immunohistochemical Analyses. [PDF]

Int J Mol Sci
Giampietri C, Somma F, Pizzichini E, D'Arcangelo D, Rahimi S, Fabrizi C, Facchiano A.   +6 more
europepmc   +1 more source

Network based approach identifies miR‐145‐3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma

The Journal of Pathology, EarlyView.
Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C‐cells and accounts for 1–5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis.
Anna Citarella, Manuela Petti, Zein Mersini Besharat, Caterina Alfano, Elena Splendiani, Sofia Trocchianesi, Sara Cassandro, Martina Chiacchiarini, Claudia Sabato, Francesca Gianno, Tanja Milena Autilio, Martina Brunetti, Giuseppina Catanzaro, Antonella Verrienti, Rossella Elisei, Raffaele Ciampi, Cristina Romei, Maria Grazia Castagna, Silvia Cantara, Vincenzo Marotta, Luciano Pezzullo, Lorenzo Farina, Cosimo Durante, Agnese Po, Elisabetta Ferretti   +24 more
wiley   +1 more source

Unveiling Disulfidptosis and Cuproptosis Vulnerabilities in Pterygium: A Transcriptomic Analysis and In-Silico Drug Repurposing Strategy. [PDF]

Genes (Basel)
Sarıkaya İ, Kılıç R.
europepmc   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Expression quantitative trait methylation across multiple cancer types with functional and therapeutic characterization using Onco-eQTM. [PDF]

NAR Genom Bioinform
Teja Korra B, Nishana M, Kumar R.
europepmc   +1 more source

Subtype‐specific prognostic relevance of IL6 in basal‐like breast cancer and modulation of IL6 expression by nanobacteria‐like particles in MDA‐MB‐231 cells

Precision Medical Sciences, EarlyView.
High IL6 expression correlates with shorter relapse‐free survival in the basal‐like breast cancer subtype. Nanobacteria‐like particles (NB‐LPs) significantly reduce breast cancer cell viability and IL6 expression levels in MDA‐MB‐231 cells. Abstract Breast cancer is one of the most prevalent malignancies among women worldwide.
Fateme Nikakhtar, Masoumeh Nezhadali, Behnaz Esfandiari   +2 more
wiley   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile. [PDF]

Mol Oncol
He L, Welsh M.
europepmc   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

MAPK-driven glioma progression and reprogramming of the tumor-associated immune response. [PDF]

Neuro Oncol
Hashemi E, Akshaya RL, Wang L, Bergland S, Piyadasa H, Ranek JS, Voong V, Kshirsagar A, Shai A, Oberlton B, Kumar A, Berger MS, Chang EF, Oldham MC, Prins RM, Bendall SC, Angelo M, Hervey-Jumper SL, Okada H, Diaz A, Phillips JJ.   +20 more
europepmc   +1 more source