Results 31 to 40 of about 282,173 (256)

Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs

BMC Pharmacology and Toxicology, 2019
Background Anti-neoplastic agents are widely used in the treatment of cancer and some non-neoplastic diseases. These drugs have been proved to be carcinogens, teratogens, and mutagens.
Maral Ramazani, Razieh Pourahmad Jaktaji, Farshad H. Shirazi, Maria Tavakoli-Ardakani, Ahmad Salimi, Jalal Pourahmad   +5 more
doaj   +1 more source

PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

Biology, 2013
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats.
Bruno Moncharmont, Ciro Abbondanza, Caterina De Rosa, Erika Di Zazzo   +3 more
doaj   +1 more source

NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint

Life, 2022
An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by NSD1 mutations are largely uncharacterized.
Giuseppina Conteduca, Davide Cangelosi, Simona Coco, Michela Malacarne, Chiara Baldo, Alessia Arado, Rute Pinto, Barbara Testa, Domenico A. Coviello   +8 more
doaj   +1 more source

Transcription Profile and Pathway Analysis of the Endocannabinoid Receptor Inverse Agonist AM630 in the Core and Infiltrative Boundary of Human Glioblastoma Cells

Molecules, 2022
Background: We have previously reported that the endocannabinoid receptor inverse agonist AM630 is a potent inhibitor of isocitrade dehydrogenase-1 wild-type glioblastoma (GBM) core tumour cell proliferation.
Gareth Williams, David Chambers, Ruman Rahman, Francisco Molina-Holgado   +3 more
doaj   +1 more source

Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations

Cancer Medicine, 2023
Background Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characterized by a high
Tatsuhiro Sato, Ken Akao, Ayuko Sato, Tohru Tsujimura, Satomi Mukai, Yoshitaka Sekido   +5 more
doaj   +1 more source

Intrinsic noise of microRNA-regulated genes and the ceRNA hypothesis [PDF]

PLoS ONE 8(8): e72676 (2013), 2012
MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic small non-coding RNAs (sRNAs).
arxiv   +1 more source

Walleye Dermal Sarcoma Virus: Molecular Biology and Oncogenesis

Viruses, 2010
Retroviruses have been detected in most vertebrate species and are etiologic agents of a variety of neoplastic diseases. The study of retroviruses has been instrumental in uncovering the molecular mechanisms responsible for oncogenesis. Retroviruses have
Sandra L. Quackenbush, Joel Rovnak
doaj   +1 more source

The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin. [PDF]

PLoS ONE, 2012
Recent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this is reflected by the presence of lipid droplets which are visible in the cytoplasm of neoplastic cells in cytological preparations.
Maria R Ambrosio, Pier P Piccaluga, Maurilio Ponzoni, Bruno J Rocca, Valeria Malagnino, Monica Onorati, Giulia De Falco, Valeria Calbi, Martin Ogwang, Kikkeri N Naresh, Stefano A Pileri, Claudio Doglioni, Lorenzo Leoncini, Stefano Lazzi   +13 more
doaj   +1 more source

Transcriptomics Reveals the Mevalonate and Cholesterol Pathways Blocking as Part of the Bacterial Cyclodipeptides Cytotoxic Effects in HeLa Cells of Human Cervix Adenocarcinoma

Frontiers in Oncology, 2022
The incidence of human cervix adenocarcinoma (CC) caused by papillomavirus genome integration into the host chromosome is the third most common cancer among women.
Pedro E. Lázaro-Mixteco, José M. González-Coronel, Laura Hernández-Padilla, Lorena Martínez-Alcantar, Enrique Martínez-Carranza, Jesús Salvador López-Bucio, Ángel A. Guevara-García, Jesús Campos-García   +7 more
doaj   +1 more source

Master regulators as order parameters of gene expression states [PDF]

Phys. Rev. E 103, 012409 (2021), 2020
Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model. It is shown that order parameters of this model can be interpreted as concentrations of master transcription regulators that form concurrent positive feedback loops with a large number of downstream regulated genes.
arxiv   +1 more source