Results 31 to 40 of about 1,031,970 (204)

"Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells"

Cancer Cell International, 2006
Background p27(Kip1) is a cyclin-dependent kinase inhibitor. When up-regulated, p27 inhibits G1-to-S phase transition of the cell cycle. This report addresses the question of whether various nutritional and chemopreventive anti-cancer agents up-regulate ...
Eto Isao
doaj   +1 more source

The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]

, 2018
Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila, Badiali, Manuela, Besharat, Zein Mersini, Capper, David, Carai, Andrea, Catanzaro, Giuseppina, Chiacchiarini, Martina, Ferretti, Elisabetta, Giangaspero, Felice, Locatelli, Franco, Marras, Carlo Efisio, Mascelli, Samantha, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese, Raso, Alessandro, Schrimpf, Daniel, Stichel, Damian, Tartaglia, Marco, von Deimling, Andreas   +19 more
core   +1 more source

Cellular interactions in the tumor microenvironment: the role of secretome [PDF]

, 2019
Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro, da Cunha, Bianca Rodrigues, Domingos, Célia, Henrique, Tiago, Polachini, Giovana Mussi, Stefanini, Ana Carolina Buzzo, Tajara, Eloiza Helena   +6 more
core   +1 more source

Genomics and proteomics approaches to the study of cancer-stroma interactions

BMC Medical Genomics, 2010
Background The development and progression of cancer depend on its genetic characteristics as well as on the interactions with its microenvironment.
Fukuyama Erica E, Teixeira Rodrigo AP, Souza Caique F, Henrique Tiago, Cunha Bianca R, Carmona-Raphe Juliana, Maniglia José V, Polachini Giovana M, Vidotto Alessandra, Peitl Paulo, Rodrigues-Lisoni Flávia C, Michaluart Pedro, de Carvalho Marcos B, Oliani Sonia M, Tajara Eloiza H   +14 more
doaj   +1 more source

Analysis of High-Risk Neuroblastoma Transcriptome Reveals Gene Co-Expression Signatures and Functional Features

Biology, 2023
Neuroblastoma represents a neoplastic expansion of neural crest cells in the developing sympathetic nervous system and is childhood’s most common extracranial solid tumor.
Mónica Leticia Martínez-Pacheco, Enrique Hernández-Lemus, Carmen Mejía   +2 more
doaj   +1 more source

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources

The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC) [PDF]

, 2020
Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety.
D'Alessi S, Ferrara S, Florena AM, Galletti B, Galletti F, Gargano R, Greco G, Verro .   +7 more
core   +1 more source

Calcitriol stimulates gene expression of cathelicidin antimicrobial peptide in breast cancer cells with different phenotype

Journal of Biomedical Sciences, 2016
BackgroundIn normal and neoplastic cells, growth-promoting, proangiogenic, cytotoxic and pro-apoptotic effects have all been attributed to cathelicidin antimicrobial peptide (CAMP).
Janice García-Quiroz, R. García-Becerra, N. Santos-Martínez, E. Avila, F. Larrea, L. Díaz   +5 more
semanticscholar   +1 more source

Analysis of apoptosis related genes in nurses exposed to anti-neoplastic drugs

BMC Pharmacology and Toxicology, 2019
Background Anti-neoplastic agents are widely used in the treatment of cancer and some non-neoplastic diseases. These drugs have been proved to be carcinogens, teratogens, and mutagens.
Maral Ramazani, Razieh Pourahmad Jaktaji, Farshad H. Shirazi, Maria Tavakoli-Ardakani, Ahmad Salimi, Jalal Pourahmad   +5 more
doaj   +1 more source

PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation

Biology, 2013
PRDM (PRDI-BF1 and RIZ homology domain containing) protein family members are characterized by the presence of a PR domain and a variable number of Zn-finger repeats.
Bruno Moncharmont, Ciro Abbondanza, Caterina De Rosa, Erika Di Zazzo   +3 more
doaj   +1 more source