Results 41 to 50 of about 1,031,970 (204)

NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint

Life, 2022
An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by NSD1 mutations are largely uncharacterized.
Giuseppina Conteduca, Davide Cangelosi, Simona Coco, Michela Malacarne, Chiara Baldo, Alessia Arado, Rute Pinto, Barbara Testa, Domenico A. Coviello   +8 more
doaj   +1 more source

Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma [PDF]

, 2012
Background: Hodkin s lymphoma is one of the most frequent lymphoma in western world. Despite an overall good prognosis some patients suffer relapsing tumors which are difficult to cure.
Benz, Alexander, Christoph, Renné, Hansmann, Martin L.   +2 more
core   +2 more sources

Regulation of Expression and Latency in BLV and HTLV

Viruses, 2020
Human T-lymphotrophic virus type 1 (HTLV-1) and Bovine leukemia virus (BLV) belong to the Deltaretrovirus genus. HTLV-1 is the etiologic agent of the highly aggressive and currently incurable cancer adult T-cell leukemia (ATL) and a neurological disease ...
A. Pluta, J. Jaworski, R. Douville
semanticscholar   +1 more source

Transcriptional Factors in the Cochlea Within the Inner Ear

Journal of Pharmacological Sciences, 2005
Differential regulation of gene expression by transcription factors is widely viewed as one of the principal mechanisms guiding development. Although numerous DNA binding proteins have been identified in various tissues, the role of individual ...
Reiko Nagashima, Chie Sugiyama, Masanori Yoneyama, Kiyokazu Ogita   +3 more
doaj   +1 more source

Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations

Cancer Medicine, 2023
Background Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole‐genome analysis has revealed that mesothelioma is characterized by a high
Tatsuhiro Sato, Ken Akao, Ayuko Sato, Tohru Tsujimura, Satomi Mukai, Yoshitaka Sekido   +5 more
doaj   +1 more source

Transcription Profile and Pathway Analysis of the Endocannabinoid Receptor Inverse Agonist AM630 in the Core and Infiltrative Boundary of Human Glioblastoma Cells

Molecules, 2022
Background: We have previously reported that the endocannabinoid receptor inverse agonist AM630 is a potent inhibitor of isocitrade dehydrogenase-1 wild-type glioblastoma (GBM) core tumour cell proliferation.
Gareth Williams, David Chambers, Ruman Rahman, Francisco Molina-Holgado   +3 more
doaj   +1 more source

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source

Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia

BMC Genomics, 2008
BackgroundThe highest rates of cervical cancer are found in developing countries. Frontline monitoring has reduced these rates in developed countries and present day screening programs primarily identify precancerous lesions termed cervical ...
Ashleen Shadeo, R. Chari, K. Lonergan, A. Pusic, Dianne Miller, T. Ehlen, D. V. van Niekerk, J. Matisic, R. Richards-Kortum, M. Follen, M. Guillaud, W. Lam, C. MacAulay   +12 more
semanticscholar   +1 more source

Walleye Dermal Sarcoma Virus: Molecular Biology and Oncogenesis

Viruses, 2010
Retroviruses have been detected in most vertebrate species and are etiologic agents of a variety of neoplastic diseases. The study of retroviruses has been instrumental in uncovering the molecular mechanisms responsible for oncogenesis. Retroviruses have
Sandra L. Quackenbush, Joel Rovnak
doaj   +1 more source

The alteration of lipid metabolism in Burkitt lymphoma identifies a novel marker: adipophilin. [PDF]

PLoS ONE, 2012
Recent evidence suggests that lipid pathway is altered in many human tumours. In Burkitt lymphoma this is reflected by the presence of lipid droplets which are visible in the cytoplasm of neoplastic cells in cytological preparations.
Maria R Ambrosio, Pier P Piccaluga, Maurilio Ponzoni, Bruno J Rocca, Valeria Malagnino, Monica Onorati, Giulia De Falco, Valeria Calbi, Martin Ogwang, Kikkeri N Naresh, Stefano A Pileri, Claudio Doglioni, Lorenzo Leoncini, Stefano Lazzi   +13 more
doaj   +1 more source