Results 201 to 210 of about 2,705,095 (358)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The genetic architecture of gene expression regulation in a <i>Citrus x Poncirus</i> hybrid tolerant to Huanglongbing. [PDF]

Front Plant Sci
Diaz IA, Zayed O, Ávila De Dios E, Jiang C, Bowman KD, Seymour DK.   +5 more
europepmc   +1 more source

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability. [PDF]

PLoS Biol, 2023
Kelliher CM, Stevenson EL, Loros JJ, Dunlap JC.   +3 more
europepmc   +1 more source

Non-reciprocal regulation ofRhodobacter capsulatusandRhodobacter sphaeroides recAgenes expression [PDF]

, 1995
Antonio R. Fernández de Henestrosa, E Rivera, Jordi Barbé   +2 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Nuclear functional role of metabolic enzymes and related metabolites: Focus on gene expression regulation. [PDF]

Mol Metab
Todisco S, Iacobazzi D, Santarsiero A, Convertini P, Infantino V.   +4 more
europepmc   +1 more source

Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media. [PDF]

Front Cell Infect Microbiol, 2022
Janoušková M, Straw ML, Su YC, Riesbeck K.   +3 more
europepmc   +1 more source

Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate.

, 1990
Serge Gangloff, Didier Marguet, Guy J.‐M. Lauquin   +2 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Elucidating the role of mycobacteriophage D29-encoded Gp36 in DNA binding and phage gene expression regulation. [PDF]

Nucleic Acids Res
Pillai SS, Jain V.
europepmc   +1 more source