Results 11 to 20 of about 1,003,870 (312)
FUNGI: FUsioN Gene Integration toolset [PDF]
Bioinformatics, 2021 Abstract Motivation Fusion genes are both useful cancer biomarkers and important drug targets. Finding relevant fusion genes is challenging due to genomic instability resulting in a high number of passenger events.
Alejandra Cervera +13 more
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Interstitial Deletions Generating Fusion Genes [PDF]
Cancer Genomics - Proteomics, 2021 A fusion gene is the physical juxtaposition of two different genes resulting in a structure consisting of the head of one gene and the tail of the other. Gene fusion is often a primary neoplasia-inducing event in leukemias, lymphomas, solid malignancies as well as benign tumors.
Panagopoulos, Ioannis, Heim, Sverre
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Interkingdom gene fusions [PDF]
Genome Biology, 2000 Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another important evolutionary phenomenon involves the evolutionary mobility of protein domains that form versatile multidomain architectures.
Y I, Wolf, A S, Kondrashov, E V, Koonin
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Unraveling the evolutionary dynamics of the TPS gene family in land plants
Frontiers in Plant Science, 2023 Terpenes and terpenoids are key natural compounds for plant defense, development, and composition of plant oil. The synthesis and accumulation of a myriad of volatile terpenoid compounds in these plants may dramatically alter the quality and flavor of ...
Xue-Mei Yan +19 more
doaj +1 more source
Microorganisms, 2021 One of the most studied metabolic routes is the biosynthesis of histidine, especially in enterobacteria where a single compact operon composed of eight adjacent genes encodes the complete set of biosynthetic enzymes.
Sara Del Duca +6 more
doaj +1 more source
A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG-CPSF6 fusion [PDF]
, 2018 Key Points Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.
Duncavage, Eric J. +13 more
core +2 more sources
Frontiers in Oncology, 2021 BCR-ABL1–positive acute leukemia can be classified into three disease categories: B-lymphoblastic leukemia (B-ALL), acute myeloid leukemia (AML), and mixed-phenotype acute leukemia (MPAL).
Jaewoong Lee +15 more
doaj +1 more source
Eccrine Poroma: Pathogenesis, New Diagnostic Tools and Association with Porocarcinoma—A Review
Diagnostics, 2023 Eccrine poroma (EP) is a relatively rare benign adnexal neoplasm that usually affects elderly patients. Its pathogenesis is still under investigation, but recent gene studies have revealed gene fusions as key incidences resulting in oncogenetic pathways.
Eirini Kyrmanidou +7 more
doaj +1 more source
Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells [PDF]
, 2008 Creative Commons Attribution-NonCommercial-Share Alike 3.0 license (CC BY-NC SA)Aim: To investigate the existence of TMPRSS2:ERG fusion gene in circulating tumor cells (CTC) from prostate cancer patients and its potential in monitoring tumor metastasis ...
Bryan D. Young +16 more
core +1 more source
Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. [PDF]
, 2018 Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 and CD68 co-expression. Despite the distinct findings, accurate diagnosis of fibrolamellar carcinoma continues to be a challenge.
Alves, Venancio Af +27 more
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