Results 41 to 50 of about 1,003,870 (312)

Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity [PDF]

, 1978
INFECTION of mice with viruses can generate cytotoxic T lymphocytes (CTL) which show restricted specificity for target cell lysis. Specific lysis requires that the virus used to prime the target cells must be of the same type as that used to sensitise ...
A Munro, A Scheid, H Tozawa, JW Schrader, K Sugamura, M Homma, MARY-JANE GETHING, MICHAEL WATERFIELD, RM Zinkernagel, U Koszinowski, U Koszinowski, ULRICH KOSZINOWSKI, Y Hosaka   +12 more
core   +1 more source

The rapidly changing field of predictive biomarkers of non-small cell lung cancer

Pathology and Oncology Research
Lung cancer is a leading cause of cancer-related death worldwide in both men and women, however mortality in the US and EU are recently declining in parallel with the gradual cut of smoking prevalence.
László József Tóth, Attila Mokánszki, Gábor Méhes   +2 more
doaj   +1 more source

Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model

Neoplasia: An International Journal for Oncology Research, 2007
Recent studies have established that a significant fraction of prostate cancers harbor a signature gene fusion between the 5' region of androgen-regulated TMPRSS2 and an ETS family transcription factor, most commonly ERG.
Kirsten D. Mertz, Sunita R. Setlur, Saravana M. Dhanasekaran, Francesca Demichelis, Sven Perner, Scott Tomlins, Joëlle Tchinda, Bharathi Laxman, Robert L. Vessella, Rameen Beroukhimt, Charles Lee, Arul M. Chinnaiyan, Mark A. Rubin   +12 more
doaj   +1 more source

Over-expression of a chimeric gene of the transcriptional co-activator MBF1 fused to the EAR repressor motif causes developmental alteration in Arabidopsis and tomato [PDF]

, 2008
Transcriptional co-activators of the Multiprotein Bridging Factor1 (MBF1) type belong to a multigenic family that encode key components of the machinery controlling gene expression by communicating between transcription factors and the basal ...
Bouzayen, Mondher, Hommel, Marie, Jaimes-Miranda, Fabiola, Khalil-Ahmad, Qaiser, Latché, Alain, Mila, Isabelle, Pech, Jean-Claude, Pouzet, Cécile, Regad, Farid   +8 more
core   +1 more source

From genomic spectrum of NTRK genes to adverse effects of its inhibitors, a comprehensive genome-based and real-world pharmacovigilance analysis

Frontiers in Pharmacology
Introduction: The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions has facilitated the development of precision oncology. Two first-generation NTRK inhibitors (larotrectinib and entrectinib) are currently approved for the treatment ...
Zhiwei Cui, Zhen Zhai, De Xie, Lihui Wang, Feiyan Cheng, Siyu Lou, Fan Zou, Rumeng Pan, Shixue Chang, Haoyan Yao, Jing She, Yidan Zhang, Xinyuan Yang   +12 more
doaj   +1 more source

The impact of tandem duplication on gene evolution in Solanaceae species

Journal of Integrative Agriculture, 2022
Whole genome duplication (WGD) and tandem duplication (TD) are important modes of gene amplification and functional innovation, and they are common in plant genome evolution.
Yi-le HUANG, Ling-kui ZHANG, Kang ZHANG, Shu-min CHEN, Jian-bin HU, Feng CHENG   +5 more
doaj   +1 more source

Uncovering the Localization and Function of a Novel Read-Through Transcript ‘TOMM40-APOE’

Cells, 2023
Recent advancements in genome analysis technology have revealed the presence of read-through transcripts in which transcription continues by skipping the polyA signal. We here identified and characterized a new read-through transcript, TOMM40-APOE.
Shichen Chang, Satoru Torii, Jun Inamo, Kinya Ishikawa, Yuta Kochi, Shigeomi Shimizu   +5 more
doaj   +1 more source

ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells [PDF]

, 2016
The RhoA and RhoC GTPases act via the ROCK1 and ROCK2 kinases to promote actomyosin contraction, resulting in directly induced changes in cytoskeleton structures and altered gene transcription via several possible indirect routes.
Clark, William, Kalna, Gabriela, Olson, Michael F., Rath, Nicola   +3 more
core   +1 more source

A connection between stress and development in the multicelular prokaryote Streptomyces coelicolor [PDF]

, 2001
Morphological changes leading to aerial mycelium formation and sporulation in the mycelial bacterium Streptomyces coelicolor rely on establishing distinct patterns of gene expression in separate regions of the colony.
Bucca G., Champness W.C., Charles J. Thompson, Chater K.F., Elliot M., Elliot M.A., Gabriella H. Kelemen, Jennifer Tenor, Kelemen G.H., Kieser T., Laura Marri, Mandic-Mulec I., Mark J. Buttner, Merrick M.J., Patrick H. Viollier, Potuckova L., Price C.W., Ryding N.J., Schwedock J., Sun J., Vohradsky J., Volker U., Westpheling J., Willey J., Yang X.   +24 more
core   +1 more source

Spine fusion by gene therapy [PDF]

Gene Therapy, 2004
Over 250 000 patients each year undergo a spine fusion procedure in the US. This constitutes 50% of all bone graft procedures. Despite best efforts, a large percentage of spine fusions (up to 35%) fail to form a solid bony arthrodesis. This is a significant clinical problem and has led to research in bone formation biology to augment spine fusion rates.
S T, Yoon, S D, Boden
openaire   +2 more sources